Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Deformed wing virus (DWV) infection is believed to be closely associated with colony losses of honeybee (Apis mellifera) due to reduced learning and memory of infected bees. The adenosine (Ado) pathway is important for maintaining immunity and memory function in animals, and it enhances antivirus responses by regulating carbohydrate metabolism in insects. Nevertheless, its effect on the memory of invertebrates is not yet clear. This study investigated how the Ado pathway regulates energy metabolism and memory in honeybees following DWV infection. Decreased Ado receptor (Ado-R) expression in the brain of infected bees resulted in a carbohydrate imbalance as well as impairments of glutamate-glutamine (Glu-Gln) cycle and long-term memory. Dietary supplementation with Ado not only increased the brain energy metabolism but also rescued long-term memory loss by upregulating the expression of memory-related genes. The present study demonstrated the regulation of the Ado pathway upon DWV infection and provides insights into the mechanisms underlying energy regulation and the neurological function of honeybees.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ibmb.2021.103674 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Landscape-scale virome analysis uncovers endemic and emerging honey bee viruses in the Silk-Road hub of Uzbekistan.
J Invertebr Pathol
August 2025
Department of Plant Medicals, Gyeongkuk National University, Andong, Republic of Korea; Agriculture Research Institute, Gyeongkuk National University, Andong, Republic of Korea. Electronic address:
Honey bee health is increasingly threatened worldwide by a complex and evolving viral landscape; however, this aspect in Central Asia remains understudied despite the region being strategically positioned along historic and modern trade routes. In 2024, we conducted a nationwide virome survey of Apis mellifera across 32 cities in 11 regions of Uzbekistan, combining the metagenomic data of 14 pooled RNA-seq libraries with RT-PCR validation and phylogenetic analyses. High-quality sequencing yielded an average of approximately 60 million reads per pool.
View Article and Find Full Text PDFInteractions of husbandry, landscape, and immunity in regulating viral loads for managed honey bees.
Biol Open
August 2025
University of Central Florida, Biological Sciences Building, 4110 Libra Dr., Orlando FL 32816, USA.
The western honey bee, Apis mellifera, continues to experience widespread die-offs that threaten their critical ecological and agricultural roles. Given the recognized impact of viruses on the increased mortality rates, it is imperative to understand the forces shaping viral infections. In this study we explore how hive husbandry, landscape, and immunity influence viral loads in managed bees.
View Article and Find Full Text PDFRNA viruses often comprise multiple variants that co-circulate in a host population, with potentially complex dynamics. Deformed wing virus (DWV), arguably the most impactful virus of honey bees (), nowadays exists as two major variants, genotypes A (DWV-A) and B (DWV-B), which provide an amenable window into the dynamics of multi-variant pathogens. DWV-B has increased in prevalence over the past two decades in honey bees in Europe, largely replacing DWV-A.
View Article and Find Full Text PDFInapparent virus infections differentially affect honey bee flight.
Sci Adv
August 2025
Department of Plant Sciences and Plant Pathology, Montana State University, Bozeman, MT, USA.
Honey bee colony deaths are associated with viruses, which frequently do not cause morphological symptoms in adult bees. To assess the impact of these inapparent infections, we measured flight performance as a proxy for honey bee health. We hypothesized that deformed wing virus (DWV) and/or sacbrood virus (SBV) would reduce flight performance and that coinfections would have compounding, negative impacts.
View Article and Find Full Text PDFThe Effects of Artificial Diets Containing Free Amino Acids Versus Intact Proteins on Biomarkers of Nutrition and Deformed Wing Virus Levels in the Honey Bee.
Insects
April 2025
Honey Bee Research Laboratory, United States Department of Agriculture, Beltsville, MD 20705, USA.
Pollen is bees' primary source of proteins. Using pollen substitutes could reduce colony losses in areas with limited floral resources. In this study, we compared the effects of pollen substitutes made from intact proteins versus free amino acids on bee survival, as well as the levels of vitellogenin (), major royal jelly protein 1 (), and deformed wing virus (DWV).
View Article and Find Full Text PDF