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In this work, we present the Wisconsin Oscillator, a small, inexpensive, low-power circuit for powering ion-guiding devices such as multipole ion guides, ion funnels, active ion-mobility devices, and non-mass-selective ion traps. The circuit can be constructed for under $30 and produces two antiphase RF waveforms of up to 250 V in the high kilohertz to low megahertz range while drawing less than 1 W of power. The output amplitude is determined by a 0-6.5 VDC drive voltage, and voltage amplification is achieved using a resonant LC circuit, negating the need for a large RF transformer. The Wisconsin Oscillator automatically oscillates with maximum amplitude at the resonant frequency defined by the onboard capacitors, inductors, and the capacitive load of the ion-guiding device. We show that our circuit can replace larger and more expensive RF power supplies without degradation of the ion signal and expect this circuit to be of use in miniature and portable mass spectrometers as well as in home-built systems utilizing ion-guiding devices.
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http://dx.doi.org/10.1021/jasms.1c00247 | DOI Listing |
Am J Speech Lang Pathol
September 2025
Department of Surgery, University of Wisconsin-Madison.
Purpose: The aim of this study was to determine the age at which children with voice disorders can complete videostroboscopy, acoustic, and aerodynamic voice assessments. Factors predicting videostroboscopy tolerance were examined.
Method: A retrospective observational cohort design was used.
Radiol Cardiothorac Imaging
October 2025
Edinburgh Imaging and Centre for Cardiovascular Science, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Functional thoracic MRI provides regional assessment of the three principal components of lung function: ventilation, perfusion, and gas exchange. It offers advantages over pulmonary function tests like spirometry, which yield only global measurements. MRI enables comprehensive evaluation of respiratory mechanics, including chest wall and diaphragm motion, dynamic large airway instability, and lung ventilation using various contrast mechanisms and gas agents.
View Article and Find Full Text PDFBrain Stimul
August 2025
Lampe Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Chapel Hill, NC, 27599, USA; Department of Neurosurgery, UNC School of Medicine, Chapel Hill, NC 27599, USA; UNC Neuroscience Center, University of North Carolina at Cha
Introduction: Dorsal column stimulation (DCS) of the spinal cord is emerging as a promising new technology to treat Parkinson's disease (PD). However, optimal stimulation settings that maximize its therapeutic effect on PD symptoms are yet to be determined. To optimize DCS therapy, it is necessary to understand its impact on pathological brain oscillations and to deliver stimulation triggered by neurophysiological biomarkers of PD.
View Article and Find Full Text PDFJ Phys Chem A
July 2025
Chemistry Department, Marquette University, Milwaukee, Wisconsin 53201-1881, United States.
We explore how the fundamental problems in quantum molecular dynamics can be modeled using classical simulators (emulators) of quantum computers and the actual quantum hardware available to us today. The list of problems we tackle includes propagation of a free wave packet, vibration of a harmonic oscillator, and tunneling through a barrier. Each of these problems starts with the initial wave packet setup.
View Article and Find Full Text PDFBiol Psychiatry
June 2025
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address:
Although not included in current diagnostic criteria, sleep disturbances are common in patients with schizophrenia (SCZ) and significantly impact their cognitive function and clinical outcomes. Among sleep disturbances, abnormalities in sleep spindles-non-rapid eye movement thalamocortical oscillations essential for sleep stability and memory consolidation-have emerged as potential neurophysiological biomarkers of SCZ. Sleep spindle deficits, particularly reduced density and duration, are consistently observed across illness stages and correlate with cognitive impairments, including working memory and attentional deficits, in individuals with SCZ.
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