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Penetrating aortic ulcers typically occur in severely diseased vessels. We present the case of a 46-year-old woman, without extensive atherosclerosis, who had sudden cardiac arrest related to ischemia from a mobile intraluminal aortic thrombus adherent to a penetrating ulcer in the ascending aorta. ().
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8543156 | PMC |
http://dx.doi.org/10.1016/j.jaccas.2021.08.002 | DOI Listing |
Am Heart J
September 2025
Baylor Scott and White Research Institute and HealthCare, Dallas TX. Electronic address:
Background: Current recommendations for a prophylactic (primary prevention) implantable cardioverter defibrillator (ICD) in patients with both ischemic and non-ischemic heart failure with reduced ejection fraction (HFrEF) originate from clinical trials conducted in selected patients over 20 years ago that showed an overall statistically significant survival benefit associated with a primary prevention ICD in the range of 23%-34%. The recent introduction of angiotensin receptor-neprilysin inhibitors [ARNI] and sodium glucose co-transporter 2 inhibitors [SGLT2i]) was shown to further reduce the risk of sudden cardiac death (SCD) in patients with HFrEF. Thus, there is an unmet need appropriately designed comparative effectiveness clinical trials aimed to reassess the survival benefit of a primary prevention ICD in contemporary patients with HFrEF.
View Article and Find Full Text PDFBiochem Biophys Res Commun
September 2025
CERVO Brain Research Centre, Quebec City, QC, Canada; Department of Medicine, Faculty of Medicine, Université Laval, Quebec City, QC, Canada. Electronic address:
Brugada syndrome is a rare inherited cardiac arrhythmia disorder primarily characterized by ventricular fibrillation, which can lead to sudden cardiac death. It follows an autosomal dominant pattern of inheritance and is most associated with dysfunction of the cardiac sodium channel Nav1.5.
View Article and Find Full Text PDFJACC Case Rep
September 2025
Department of Internal Medicine, Denia Hospital, Alicante, Spain.
Background: Propionic acidemia (PA) is a rare autosomal recessive metabolic disorder, typically presenting in infancy. Cardiac involvement in adults is uncommon and underrecognized.
Case Summary: A previously healthy 20-year-old man suffered an out-of-hospital cardiac arrest caused by ventricular fibrillation.
Poult Sci
August 2025
Centre for Genetic Improvement of Livestock, Department of Animal Biosciences, University of Guelph, Guelph, ON, Canada; Centre for Nutrition Modelling, Department of Animal Biosciences, University of Guelph, Guelph, ON, Canada; Department of Animal and Veterinary Sciences, Aarhus University, Bliche
Late-stage mortality is a significant challenge for the poultry industry, leading to substantial economic losses, concerns about animal welfare, and operational sustainability. Heart-related conditions, including ascites syndrome, pulmonary hypertension syndrome, hypertrophic cardiomyopathy, and sudden death syndrome, contribute significantly to this issue. The increasing prevalence of these conditions is potentially linked to intense selection pressure aimed at maximizing meat yield, particularly breast meat.
View Article and Find Full Text PDFEuropace
September 2025
APHP, Département de Cardiologie, Hôpital Pitié-Salpêtrière, 75013 Paris, France.