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http://dx.doi.org/10.1186/s13075-021-02640-6 | DOI Listing |
Arthritis Res Ther
October 2021
Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Rinker Health Sciences Campus, 9401 Jeronimo Road, Irvine, CA, 92618, USA.
Neoplasia
November 2007
Norlux Neuro-Oncology, Department of Biomedicine, University of Bergen, Bergen N-5009, Norway.
Malignant primary brain tumors are characterized by a short median survival and an almost 100% tumor-related mortality. Despite the addition of new chemotherapy regimes, the overall survival has improved marginally, and radiotherapy is only transiently effective, illustrating the profound impact of treatment resistance on prognosis. Recent studies suggest that a small subpopulation of cancer stem cells (CSCs) has the capacity to repopulate tumors and drive malignant progression and mediate radio- and chemoresistance.
View Article and Find Full Text PDFJ Neurosci
May 2006
Department of Neurobiology and Behavior, State University of New York, Stony Brook, New York 11794, USA.
The NG2 chondroitin sulfate proteoglycan inhibits axon growth in vitro. Levels of NG2 increase rapidly in the glial scars that form at sites of CNS injury, suggesting that NG2 may inhibit axon regeneration. To determine the functions of NG2, we infused mixtures of neutralizing or non-neutralizing anti-NG2 monoclonal antibodies into the dorsally transected adult rat spinal cord and analyzed the regeneration of ascending mechanosensory axons anatomically.
View Article and Find Full Text PDFJ Clin Invest
October 2003
Department of Medical Biochemistry, Sahlgrenska Academy at Göteberg University, Göteborg, Sweden.
Tumor-infiltrating blood vessels deviate morphologically and biochemically from normal vessels, raising the prospect of selective pharmacological targeting. Current antiangiogenic approaches focus mainly on endothelial cells, but recent data imply that targeting pericytes may provide additional benefits. Further development of these concepts will require deeper insight into mechanisms of pericyte recruitment and function in tumors.
View Article and Find Full Text PDF