98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8517195 | PMC |
http://dx.doi.org/10.1002/clt2.12067 | DOI Listing |
JCO Precis Oncol
September 2025
Cell Biology and Biotherapy Unit, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, Napoli, Italy.
Purpose: Tumor comprehensive genomic profiling (CGP) may detect potential germline pathogenic/likely pathogenic (P/LP) alterations as secondary findings. We analyzed the frequency of potentially germline variants and large rearrangements (LRs) in the RATIONAL study, an Italian multicenter, observational clinical trial that collects next-generation sequencing-based tumor profiling data, and evaluated how these findings were managed by the enrolling centers.
Patients And Methods: Patients prospectively enrolled in the pathway-B of the RATIONAL study and undergoing CGP with the FoundationOne CDx assays were included in the analysis.
Adv Mater
September 2025
Department of Engineering, School of Computing and Engineering, University of Huddersfield, Queensgate, Huddersfield, HD1 3DH, UK.
A new family of nanostructured ternary intermetallic compounds - named the ZIP phases - is introduced in this work. The ZIP phases exhibit dualistic atomic ordering, i.e.
View Article and Find Full Text PDFAnn Hematol
September 2025
Hematology and Transplant Center, University Hospital"San Giovanni di Dio e Ruggi d'Aragona", Salerno, Italy.
Functional high risk multiple myeloma (FHRMM) remains a challenging entity with poor outcomes and limited survival, and there is no international consensus on optimal second-line therapeutic strategies in relapsed/refractory patients. In this multicenter real-world retrospective study, we investigated clinical characteristics and outcomes of a total of 62 FHRMM patients previously treated with a first-line daratumumab-based quadruplet regimen or who relapsed within 12 months after frontline autologous stem cell transplantation (ASCT). In our cohort, the overall response rate was 61%, with 42% of patients achieving a very good partial response (VGPR) or better.
View Article and Find Full Text PDFJACC Heart Fail
September 2025
Cardiovascular Pathology, Department of Cardiac, Thoracic Vascular Sciences and Public Health, University of Padova, Padova, Italy. Electronic address:
Int Arch Occup Environ Health
September 2025
Department of Mechanical Engineering, Politecnico di Milano, Milan, Italy.
Purpose: To investigate the role of personal risk factors in the occurrence of the vascular, neurological and fibroproliferative disorders of the hand-arm vibration syndrome (HAVS) in workers groups exposed to hand-transmitted vibration (HTV).
Methods: HAVS prevalence and incidence data were pooled across a series of cross-sectional studies (total sample: 1272 HTV workers, 579 controls) and prospective cohort studies (total sample: 377 HTV workers, 138 controls) conducted in Central and North-Eastern Italy. The pooled studies included detailed individual-level information about HTV exposure, personal risk factors, medical comorbidities and HAVS disorders.