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Molecular docking analysis of marine compounds with voltage gated calcium channel for potential anti-epileptic molecules.
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Toxicology and Computational Biology Group, Centre for Bioinformatics, Maharshi Dayanand University, Rohtak, Haryana, India, 124001.
Epileptic seizures are directly linked with an anomalous influx of extracellular calcium or sodium anions through voltage-gated channels disturb the chemical and electrical gradients, resulting in seizures or jerking moments. Voltage-gated calcium channel (VGCC) subunit α2δ-1 is the binding site for gabapentinoids used to treat epilepsy and neuropathic pain. However, this class of drugs showed severe side effects associated with CNS and respiratory depression.
View Article and Find Full Text PDFAnalgesic prescribing in patients with inflammatory arthritis in England: observational studies in the Clinical Practice Research Datalink.
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May 2024
Primary Care Centre Versus Arthritis, School of Medicine, Keele University, Keele, UK.
Article Synopsis
- The study aimed to examine the prescribing patterns of analgesics for patients with inflammatory arthritis (IA) over time, despite limited evidence supporting their effectiveness.
- Analgesic prescriptions remained common from 2004 to 2020, with a notable decline in overall prescription rates, while opioids became the most prescribed analgesics by 2020, and gabapentinoid use significantly increased.
- The research highlighted that analgesic prescribing varied based on factors like age, sex, and socio-economic status, indicating a misalignment with evidence-based guidelines in treating IA.
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From the CHU de Québec-Université Laval Research Center, Population Health and Optimal Health Practices Research Unit, Trauma-Emergency-Critical Care Medicine, Québec City, Québec, Canada.