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Multiscale brings great benefits for people to observe objects or problems from different perspectives. Multiscale clustering has been widely studied in various disciplines. However, most of the research studies are only for the numerical dataset, which is a lack of research on the clustering of nominal dataset, especially the data are nonindependent and identically distributed (Non-IID). Aiming at the current research situation, this paper proposes a multiscale clustering framework based on Non-IID nominal data. Firstly, the benchmark-scale dataset is clustered based on coupled metric similarity measure. Secondly, it is proposed to transform the clustering results from benchmark scale to target scale that the two algorithms are named upscaling based on single chain and downscaling based on Lanczos kernel, respectively. Finally, experiments are performed using five public datasets and one real dataset of the Hebei province of China. The results showed that the method can provide us not only competitive performance but also reduce computational cost.
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http://dx.doi.org/10.1155/2021/8993543 | DOI Listing |
MedComm (2020)
September 2025
modulates presynaptic Ca1.3 Ca channel function in inner hair cells (IHCs) and is required for indefatigable synaptic sound encoding. Biallelic variants in are associated with non-syndromic hearing loss (DFNB93).
View Article and Find Full Text PDFEur Heart J
September 2025
Institute of Pharmacology and Toxicology, University Medical Centre Göttingen, Robert-Koch-Straße 40, 37075 Göttingen, Germany.
Background And Aims: Atrial fibrillation (AF) is a prevalent complication after cardiac surgery, worsening patient outcomes. Considering the established role of Ca2+-handling abnormalities in AF pathogenesis, this study aimed to evaluate if integrating cytosolic Ca2+-handling measurements with clinical risk factors enhances the risk prediction of post-operative AF.
Methods: Clinical data from 558 patients undergoing cardiac surgery without pre-existing AF from two centres were analysed.
bioRxiv
August 2025
Department of Biomedical Engineering, Johns Hopkins University.
Neural population activity is often stereotyped into recurring activity patterns, i.e., neural motifs, which can be seen as the fundamental building blocks in sensory processing and cognition.
View Article and Find Full Text PDFBrief Bioinform
August 2025
Department of Physics, National Taiwan Normal University, 88 Sec.4 Ting-Chou Rd., Taipei 116, Taiwan.
We introduce consensus MSClustering, an unsupervised hierarchical network approach that integrates multi-omics data to identify molecular subtypes and conserved pathways across diverse cancers. Using a novel heterogeneity index, we selected 167 key genes with functionally coherent roles validated through Gene Ontology analysis. Applied to 2439 tumors spanning 10 cancer types-and successfully extended to 2675 tumors (12 types) including cases with incomplete molecular data-MSClustering demonstrated: (i) precise classification of major cancer types and breast cancer molecular subtypes; (ii) discovery of novel pan-cancer squamous metaplastic signatures; (iii) exceptional prognostic stratification (log-rank P = 2.
View Article and Find Full Text PDFMov Disord
September 2025
University Medical Center Göttingen, Department of Experimental Neurodegeneration, Center for Biostructural Imaging of Neurodegeneration, Göttingen, Germany.
Background: Parkinson's disease (PD) is a complex multifactorial disorder with a genetic component in about 15% of cases. Multiplications and point mutations in SNCA gene, encoding α-synuclein (aSyn), are linked to rare familial forms of PD.
Objective: Our goal was to assess the clinical presentation and the biological effects of a novel K58N aSyn mutation identified in a patient with PD.