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Introduction: Mini-Addenbrooke's Cognitive Examination (M-ACE) is a screening neurocognitive test with diagnostic accuracy for mild cognitive impairment and dementia. The present study aims to determine the construct validity, concurrent and divergent validity and to determine the normative equation for the Portuguese version of M-ACE.
Method: The sample is composed by 130 participants without any subjective complaint of memory loss and completely independent in daily life activities, recruited in health units, day care centers and religious and civic associations, from several districts of Portugal. The ACE-III, from which the M-ACE was extracted, and the Geriatric Depression Scale (GDS) were administered to all participants.
Results: Reliability is considered good ( = 0.844) and the item-total correlations of the M-ACE were highly significant. M-ACE showed a positive correlation with ACE-III and a negative correlation with GDS. Schooling and age were the only variables related to M-ACE performance. The obtained model from the multiple regression was significant. A normative equation was extracted from this model.
Conclusions: The Portuguese version of M-ACE has solid psychometric properties enabling its clinical use. The availability of M-ACE normative equation based on a healthy sample according to age and education enables the use of a brief screening tool for cognitive functioning. M-ACE does not require formal specialized training, it is a quick test which can be an advantage, for instance, in primary health care consultations.
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http://dx.doi.org/10.1097/j.pbj.0000000000000138 | DOI Listing |
Front Psychol
August 2025
Tokyo College, The University of Tokyo, Tokyo, Japan.
Introduction: Excessive and compulsive behaviors, including substance and behavioral addictions, represent a growing global concern. In Brazil, the increasing prevalence of these behaviors underscores the need for effective screening tools to identify individuals at risk. The Brief Screener for Substance and Behavioral Addiction (SSBA) has been recognized internationally for its utility in both clinical assessment and public health surveillance.
View Article and Find Full Text PDFAmyotroph Lateral Scler Frontotemporal Degener
September 2025
Faculdade de Medicina, Centro de Estudos Egas Moniz, Universidade de Lisboa, Lisboa, Portugal.
This study aimed to derive standardized regression-based (SRB) reliable change indices (RCIs) for the cognitive section of the Portuguese Edinburgh Cognitive and Behavioral ALS Screen (ECAS-C). Forty-nine MND patients undergoing the ECAS were followed-up (T1) at 7.2 ± 2 months (range = 5-12).
View Article and Find Full Text PDFRev Bras Enferm
September 2025
Universidade Federal do Triângulo Mineiro. Uberaba, Minas Gerais, Brazil.
Objectives: to adapt the International Pain Outcomes questionnaire into Brazilian Portuguese and evaluate its clinimetric properties.
Methods: we conducted a methodological, quantitative, validation, and cross-cultural adaptation study of the instrument. The process included translation, synthesis, expert committee review, back-translation, consensus between the English versions and comparison with the original version, pretest phase (n=30), and metric property validation (convergent validity, n=360; interobserver reliability analysis, n=54; internal consistency, n=360).
Rev Bras Enferm
September 2025
Universidade de São Paulo. Ribeirão Preto, São Paulo, Brazil.
Objectives: to develop and validate an educational booklet on HIV Pre-Exposure Prophylaxis (PrEP).
Methods: quantitative validation study aimed at developing and validating an educational booklet by experts and the target audience. For validation with experts, we used the Health Education Content Validation Index developed in a virtual environment.
Diabetologia
September 2025
Department of Science and Environment, Roskilde University, Roskilde, Denmark.
Aims/hypothesis: Upregulation of miR-146a-5p and miR-29-3p is observed in chronic non-healing wounds in diabetes. Their single or combined inhibition's molecular and cellular effects were assessed in human keratinocytes (HaCaT cells) and in vivo using a mouse model of type 1 diabetes.
Methods: As primary outcomes, we screened for proteome changes in HaCaT cells by LC-MS/MS after transfection with miR-146a-5p or miR-29a-3p inhibitors individually or in combination and following stimulation with TNF-α.