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Tunable narrow-band optical filter (TNOF) based on stimulated Brillouin scattering (SBS) has been applied in various applications such as microwave photonics and a high-resolution optical spectrum analyzer (OSA). While the frequency response of a SBS-based filter has always been an important characteristic in the reported studies, few have addressed the issue of the filter response under a continuously tuning condition. When the tuning speed is too fast, the filter response will change and cause spectral distortion. In this paper, the frequency response of SBS-TNOF under a wavelength-swept pump (i.e., continuously tuning) condition is investigated and modeled. Experimental results are in good agreement with the theoretical analysis and verify that the broadening of the SBS-TNOF response is induced by the pump wavelength difference along different positions of the fiber, which can be explained as convolution with broadband pump as well. Based on the widely used Richardson-Lucy deconvolution algorithm and proposed SBS-TNOF response model, the distorted responses are successfully reconstructed and the sweep speed dependency is almost eliminated. Commonly used on-off keying signal is tested using the proposed reconstruction method to assess its performance in the SBS-OSA. Both the overall profile and the detail of the signal spectra are significantly recovered, and the quantitatively evaluation illustrates that the feasible sweep speed can be improved from ∼45 nm/s to over 95 nm/s.
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http://dx.doi.org/10.1364/OE.434008 | DOI Listing |
Pediatr Infect Dis J
September 2025
From the Pediatric Infectious Diseases Unit, Gregorio Marañón University Hospital, Madrid, Spain.
Background: Vaccination is a key strategy to reduce infectious disease mortality. In pediatric heart transplant recipients (HTRs), the use of immunosuppressive therapy weakens immune responses, increasing the risk of viral infections. This study aimed to evaluate the immunogenicity of hepatitis B virus (HBV) revaccination in this vulnerable population.
View Article and Find Full Text PDFElife
September 2025
Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, United States.
The microglial surface protein Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) plays a critical role in mediating brain homeostasis and inflammatory responses in Alzheimer's disease (AD). The soluble form of TREM2 (sTREM2) exhibits neuroprotective effects in AD, though the underlying mechanisms remain elusive. Moreover, differences in ligand binding between TREM2 and sTREM2, which have major implications for their roles in AD pathology, remain unexplained.
View Article and Find Full Text PDFSmall
September 2025
Institute of Thin Film Physics and Applications, Shenzhen Key Laboratory of Advanced Thin Films and Applications, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, State Key Laboratory of Radio Frequency Heterogeneous Integration, College of Physic
Antimony selenide (SbSe), a narrow-bandgap semiconductor with strong light absorption, exhibits photoresponse up to ≈1050 nm due to its intrinsic 1.15 eV bandgap. To extend detection into the near-infrared (NIR, 700-1350 nm), Bi-alloyed (BiSb)Se is developed via vacuum sputtering and postselenization.
View Article and Find Full Text PDFCancer Invest
September 2025
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China.
Given the limited diagnostic technologies and treatment options available for lung adenocarcinoma (LUAD) patients with liver metastases, it is crucial to identify potential genomic signatures associated with liver metastasis, which could significantly contribute to the development of improved diagnostic tools and treatment strategies for LUAD patients with liver metastases. In this study, we identified specific genetic alterations in tumor samples with liver metastases by targeted capture sequencing. The results showed that the significantly higher mutation frequencies of , and in LUAD patients with liver metastases and and mutations found in both tumor tissues and plasma samples from patients with liver metastases.
View Article and Find Full Text PDFAnn Surg
September 2025
Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Objective: We hypothesized that anatomic location of metastatic melanoma is associated with the degree of therapeutic response to TVEC.
Summary: TVEC is the first FDA-approved injectable oncolytic virus to treat unresectable stage IIIB-IV metastatic melanoma patients. Previously published real-world outcomes demonstrated a 39% complete response (CR) rate to TVEC.