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http://dx.doi.org/10.31478/202107d | DOI Listing |
JMIR Cancer
September 2025
iCARE Secure Data Environment & Digital Collaboration Space, NIHR Imperial Biomedical Research Centre, London, United Kingdom.
Background: Electronic health records (EHRs) are a cornerstone of modern health care delivery, but their current configuration often fragments information across systems, impeding timely and effective clinical decision-making. In gynecological oncology, where care involves complex, multidisciplinary coordination, these limitations can significantly impact the quality and efficiency of patient management. Few studies have examined how EHR systems support clinical decision-making from the perspective of end users.
View Article and Find Full Text PDFEur J Gastroenterol Hepatol
September 2025
Department of General Medicine, Affiliated Anqing First People's Hospital of Anhui Medical University, Anqing, Anhui, China.
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-associated death globally. Second-line therapies are crucial for improving survival and quality of life among individuals suffering from advanced HCC who have not responded to first-line therapies. This study sought to evaluate the safety and efficacy of different second-line therapies for advanced HCC by network meta-analysis.
View Article and Find Full Text PDFEur J Gastroenterol Hepatol
August 2025
Department of Surgery, Aristotle University of Thessaloniki, Thessaloniki.
Background: The use of probiotics as a treatment for irritable bowel syndrome (IBS) is gaining attention, with recent studies indicating that certain probiotics or combinations may have mental health benefits for patients with IBS.
Aims: To systematically review and meta-analyze, using network meta-analysis (NWM), the comparative effectiveness and safety of probiotics with psychotropic potential on quality of life, depression, and anxiety in patients with IBS.
Methods: Relevant randomized controlled trials (RCTs) were analyzed, using a Bayesian NWM, to compare the performance of probiotics with mental health benefits in IBS treatment.
J Craniofac Surg
September 2025
Department of Pediatric Plastic and Reconstructive Surgery, Children's Hospital Colorado.
Background: Craniosynostosis repair is traditionally performed at high-volume academic centers with multidisciplinary teams. Access barriers in rural or suburban regions raise the question of whether comparable outcomes can be achieved and if this surgery can be performed safely in community settings.
Objective: To evaluate the safety and perioperative outcomes of cranial vault reconstruction for craniosynostosis performed at a community-based children's hospital and compare these outcomes to those reported at academic institutions.
J AOAC Int
September 2025
Analytical Development Division, Senores Pharmaceuticals, Ahmedabad, India.
Background: Molnupiravir, an FDA-approved antiviral for the treatment of COVID-19, requires reliable analytical methods to ensure its quality and safety due to its therapeutic importance.
Objectives: This study presents the development of a stability-indicating RP-HPLC method for estimating molnupiravir-related impurities in capsule formulations. An unknown impurity is structurally elucidated using LC-TQ/MS and 1H and 1³C NMR spectroscopy.