98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8473642 | PMC |
http://dx.doi.org/10.1002/ctm2.524 | DOI Listing |
World J Gastroenterol
August 2025
Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784-400, Brazil.
Background: Adenomatous polyposis confers an increased risk of developing colorectal cancer. and are the major genes investigated in patients suspected of having polyposis. In addition to and genes, other genes, such as , and , have recently been associated with polyposis phenotypes, conferring heterogeneity in terms of the clinical, etiological and heritable aspects of patients with polyposis.
View Article and Find Full Text PDFZhonghua Wei Chang Wai Ke Za Zhi
July 2025
Department of Radiation Oncology, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University; Shanghai Key Laboratory of Radiation Oncology; Shanghai Clinical Research Center for Radiation Oncology, Shanghai 200032, China.
Immunotherapy based on immune checkpoint inhibitor (ICI) has shown remarkable efficacy in the treatment of microsatellite instability (MSI)-high CRC. However, the monotherapy of ICI in microsatellite stable (MSS) CRC has not been satisfactory. Some patients with MSS CRC can benefit from various combination immunotherapy regimens.
View Article and Find Full Text PDFMod Pathol
July 2025
Hereditary Cancer Program, Catalan Institute of Oncology, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain; Program in Molecular Mechanisms and Experimental Therapy in Oncology (Oncobell), IDIBELL, Hospitalet de Llobregat, Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CI
Polymerases ε and δ maintain genome integrity through exonuclease proofreading. Germline and somatic pathogenic variants (PVs) in the exonuclease domain (ED) of POLE and POLD1 impair proofreading, causing hypermutated tumors. Despite shared mutational features that make these tumors highly immunogenic, molecular and clinical distinctions between POLE and POLD1 mutations and between somatic and germline variants remain incompletely understood.
View Article and Find Full Text PDFImmunotherapy
July 2025
Department of Gastrointestinal Medical Oncology, Moffitt Cancer Center, Tampa, FL, USA.
Immune checkpoint inhibitors have resulted in treatment paradigm changes for the management of patients with solid tumors, including microsatellite instability-high (MSI-H) colorectal cancer (CRC). Although the benefit of these agents appears to be limited for microsatellite stable (MSS) CRC, recent studies suggest that the immune microenvironment of the early-stage MSS CRC and perhaps those with advanced-stage disease without active liver metastasis may be more immune permissive where relatively more promising responses were noted. At this time, biomarkers of immunotherapy for patients with CRC have not been well-defined.
View Article and Find Full Text PDFSci Rep
May 2025
Department of Physiology & Biophysics, College of Medicine, Howard University, 520 W Street N.W, Washington, DC, 20059, USA.
Endometrial cancer (EC) is the most common gynecological malignancy. Although prognosis is favorable for patients with an early-stage disease, those with recurrent or more advanced disease have low response rates to chemotherapy and poor clinical outcomes. Previously, we have shown that DNA repair gene (NEIL3) is required for retaining replication fork integrity during replication stress.
View Article and Find Full Text PDF