Antimicrobial Resistance and Comparative Genome Analysis of Strains Isolated in Egypt.

is an important human pathogen in both developing and industrialised countries that can causes a variety of human infections, such as pneumonia, urinary tract infections and bacteremia. Like many Gram-negative bacteria, it is becoming resistant to many frontline antibiotics, such as carbapenem and cephalosporin antibiotics. In Egypt, is increasingly recognised as an emerging pathogen, with high levels of antibiotic resistance. However, few Egyptian strains have been sequenced and characterised. Hence, here, we present the genome sequence of a multidrug resistant strain, KPE16, which was isolated from a child in Assiut, Egypt. We report that it carries multiple antimicrobial resistance genes, including a carbapenemase and extended spectrum β-lactamase genes (i.e., , , and ). By comparing this strain with other Egyptian isolates, we identified common plasmids, resistance genes and virulence determinants. Our analysis suggests that some of the resistance plasmids that we have identified are circulating in strains in Egypt, and are likely a source of antibiotic resistance throughout the world.