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http://dx.doi.org/10.1111/ijlh.13709 | DOI Listing |
Front Oncol
August 2025
Department of Diagnostic Innovation, Pathology Unit 2, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.
Introduction: Ovarian cancer (OC) is one of the leading causes of cancer-related death in women worldwide. Treatment with PARP-inhibitors has significantly improved survival in patients with high-grade serous cancer (HGSC) bearing mutations (~22% of the cases), and/or homologous recombination deficiency (HRD, ~50%). Unfortunately, limited therapeutic alternatives are available for wild type/HR proficient HGSC patients, who usually exhibit resistance to standard treatments and poor prognosis.
View Article and Find Full Text PDFJ Adv Pract Oncol
May 2025
From Northeast Georgia Medical Center, Gainesville, Georgia.
In developed countries, the lifetime risk of developing breast cancer among women is 11%. Therefore, screening asymptomatic women for breast cancer is widely accepted as preventive health care. Mammography is the primary imaging modality for the detection of breast abnormalities.
View Article and Find Full Text PDFWorld J Urol
June 2025
Urology Department, Bordeaux University Hospital, 1 Place Amelie Raba Leon, Bordeaux, 33000, France.
Purpose: International guidelines present discrepancies concerning restaging transurethral resection (TURBT) for high-grade (HG) Ta bladder cancer. Recent studies with heterogeneous inclusion criteria have reported discordant results regarding its benefits. Our study aimed to assess the prognostic impact of restaging TURBT in patients with HG Ta that was fully resected during the initial TURBT.
View Article and Find Full Text PDFJ Pathol Inform
April 2025
Department of Pathology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA.
Objective: Early detection and removal of suspicious polyps during routine colonoscopies play an important role in reducing the risk of colorectal cancer. Patient management and follow-up are determined by the type of polyps removed and the degree of dysplasia present on histological evaluation. Whereas discerning between a benign polyp and a dysplastic one is a trivial task, distinguishing between tubular adenomas with low-grade dysplasia (LGD) and high-grade dysplasia (HGD) is a challenging task.
View Article and Find Full Text PDFRadiol Med
June 2025
Department of Medical Imaging, MAGINE UR UM 103, Nîmes University Hospital, Montpellier University, 30029, Nîmes, France.
Background: The spleen is frequently injured in blunt abdominal trauma, and proper management depends on accurate CT assessment using the AAST-OIS scoring system. However, the reproducibility of CT scoring in trauma patients remains uncertain.
Purpose: To assess the reproducibility of AAST-OIS scoring for high-grade splenic injuries (grades 3, 4, and 5) without vascular anomalies on initial CT scans and to evaluate the clinical impact of misclassification, particularly in relation to hemorrhagic complications.