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http://dx.doi.org/10.1214/19-STS724 | DOI Listing |
Drug Saf
September 2025
The MITRE Corporation, 202 Burlington Rd, Bedford, MA, 01730, USA.
Acta Anaesthesiol Scand
October 2025
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Introduction: Sepsis remains a leading cause of mortality, with mortality from septic shock exceeding 40%. Standardized resuscitation (30 mL/kg) may cause adverse outcomes, including fluid overload or prolonged hypotension, emphasizing the need for individualized strategies. Sepsis-induced shock arises from varying degrees of vasodilation and hypovolemia, yet patients often present with similar clinical signs in the emergency department (ED).
View Article and Find Full Text PDFActa Anaesthesiol Scand
October 2025
Centre for Anaesthesiological Research, Department of Anaesthesiology, Zealand University Hospital, Køge, Denmark.
Background: Multiple organ dysfunction syndrome (MODS) in critical illness involves dysregulated immune and inflammatory responses, endotheliopathy, and coagulation activation. We investigated how three types of endotheliopathy biomarkers relate to pro- and anti-inflammatory responses and clinical outcomes in intensive care unit (ICU) patients.
Methods: In this secondary, explorative analysis of a prospective single-centre cohort (n = 459), we assessed associations between endotheliopathy biomarkers (syndecan-1, soluble thrombomodulin (sTM), platelet endothelial cell adhesion molecule-1 (PECAM-1)) and inflammatory biomarkers (pro-inflammatory: IFN-ϒ, IL-1β, IL-2, IL-6, IL-8, IL-12p70, TNF-α; anti-inflammatory: IL-4, IL-10, IL-13) at ICU admission using linear regression.
Biom J
October 2025
Department of Medical Biometry, Institute for Quality and Efficiency in Health Care (IQWiG), Cologne, Germany.
Hazards constitute key quantities for analyzing, interpreting, and understanding time-to-event data. Hazards and corresponding effect measures, such as the hazard ratio from the Cox proportional hazards model, have a valid causal interpretation if the hazard function is considered as a function in time rather than hazards at specific time points. In this comment, we would like to add two points: (1) The hazard ratio is also a useful population-level estimand with a valid causal interpretation.
View Article and Find Full Text PDFInt J Surg
September 2025
The Affiliated Nanhai Hospital of Traditional Chinese Medicine of Jinan University, Foshan, China.