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Article Abstract
In this study, a centrifugal partition chromatography (CPC) separation was applied to identify antioxidant-responsive element (ARE) induction molecules from the crude extract of roots. CPC was operated with a two-phase solvent system composed of -hexane-methanol-water (10:8.5:1.5, //) in dual mode (descending to ascending), which provided a high recovery rate (>95.5%) with high resolution. Then, ARE induction activity of obtained CPC fractions was examined in ARE-transfected HepG2 cells according to the weight ratios of the obtained fractions. The fraction exhibiting ARE-inducing activity was further purified by preparative HPLC that led to isolation of two eudesmane type sesquiterpenes as active compounds. The chemical structures were elucidated as linderolide U () and a new sesquiterpene named as linderolide V () by spectroscopic data. Further bioactivity test demonstrated that compounds and enhanced ARE activity by 22.4-fold and 7.6-fold, respectively, at 100 μM concentration while 5 μM of sulforaphane induced ARE activity 24.8-fold compared to the control.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8433645 | PMC |
| http://dx.doi.org/10.3390/molecules26175269 | DOI Listing |
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