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Metastasis to the skin and orbit from bladder cancer is extremely rare. A 76-year-old diabetic male presented with skin nodules and proptosis of the left eye. Punch biopsy from the abdominal wall nodule showed malignant cells with perineural invasion. Immunohistochemistry showed features suggestive of metastatic urothelial carcinoma. We present this case of urothelial carcinoma of the urinary bladder presenting primarily with highly unusual nodular skin metastasis.
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http://dx.doi.org/10.4103/iju.IJU_461_20 | DOI Listing |
J Surg Case Rep
September 2025
Department of Dermatology and Sexually Transmitted Disease, Tishreen University Hospital, Lattakia 041, Syria.
Hepatoid adenocarcinoma of the lung (HAL) is a rare and aggressive subtype of pulmonary adenocarcinoma, with cutaneous metastasis being an uncommon clinical manifestation. A 49-year-old male presented with a painful, nodular skin lesion on the upper back. Histopathological examination confirmed it as a cutaneous metastasis of HAL.
View Article and Find Full Text PDFFront Med (Lausanne)
August 2025
Department of Dermatology, Venereology and Leprosy, Datta Meghe Institute of Higher Education and Research, Wardha, India.
Leprosy, induced by , and in some cases, , remains an important public health issue in endemic regions despite ongoing elimination efforts. Histoid Hansen's disease, a variant of lepromatous leprosy, is characterised by shiny, well-defined nodules and a heavy acid-fast bacillary load. We present a case of a 50-year-old male agricultural worker from rural central India presenting during a community health camp with multiple cutaneous nodules clinically suggestive of histoid leprosy.
View Article and Find Full Text PDFRadiol Case Rep
November 2025
Radiology Department Aga Khan University Hospital, Pakistan.
Fumarate hydratase (FH) deficient uterine leiomyomas account for only 0.4 % of all uterine leiomyomas. They have some unique histological characteristics and can be linked to renal cell carcinoma (HLRCC) syndrome and hereditary leiomyomatosis.
View Article and Find Full Text PDFItal J Dermatol Venerol
August 2025
Dermatology Section, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Prurigo nodularis (PN) is a chronic skin inflammatory condition characterized by severe, persistent itching and excoriated nodules induced by scratching. PN is strongly related to neural and immune dysfunction and negatively impacts quality of life. Treatments for PN are often off-label, highlighting the need for specifically approved agents and consensus guidelines for patient management.
View Article and Find Full Text PDFJ Cosmet Dermatol
September 2025
Department of Dermatology, College of Medicine, Imam Mohammad Bin Saud University, Riyadh, Saudi Arabia.
Background: Necklines are a common complaint in patients as they are a sign of aging. Hyaluronic acid (HA) fillers are widely used to address volume loss and linear depressions. HA fillers are safe, effective, and versatile, but their use for necklines is not well-documented in the literature.
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