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A longitudinal retrospective study was carried out to investigate the attrition of Thoroughbred (TB) and Standardbred (SB) horses racing at New York racetracks during the 2016 to 2019 seasons. The data were collected from the New York State Gaming Commission (NYSGC) Equine Breakdown, Death, Injury and Incident (EBDII), The Jockey Club InCompass Solutions, and The United States Trotting Association Pathway databases. Survival analysis was used to compare the predisposing factors by breed of the horse. The study included 431 horses (360 TB and 71 SB). There was a significant difference between the average incidence of attrition events per start for TB (0.304) and SB (0.035) horses. There was a significant difference in the median age to attrition between TB (4.2 years) and SB (7.5 years) horses. There was also a significant difference between the average number of starts to attrition for TB (13.6) and SB (125.5) horses. Among the causes of attrition events in the two breeds musculoskeletal injuries and medical conditions were significantly higher among TB horses, while sudden death was significantly higher among SB horses. The multivariate analysis showed that the hazard of attrition was affected by the age of the horse, age at first start, whether the horse was intact male, type of activity (racing training or other) and the breed of the horse. SB horses were less likely to experience attrition events in comparison to TB horses.
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http://dx.doi.org/10.1016/j.jevs.2021.103703 | DOI Listing |
Eur Respir Rev
July 2025
Department of Imaging and Pathology, Biomedical MRI, KU Leuven, Leuven, Belgium
Pulmonary fibrosis remains a devastating and often fatal condition due to the lack of effective treatments that halt disease progression. Rodent models of pulmonary fibrosis are crucial to identify candidate targets and novel therapeutic agents. However, the attrition rate of novel drug candidates in clinical trials remains high.
View Article and Find Full Text PDFVaccine
September 2025
Centre for Quantitative Medicine, Duke-NUS Medical School, 20 College Road, 169856, Singapore; Signature Programme in Health Services & Systems Research, Duke-NUS Medical School, 8 College Road, 169857, Singapore; Tampere Center for Child, Adolescent and Maternal Health Research, Tampere University,
The Cox model and its extensions assuming proportional hazards is widely used to estimate vaccine efficacy (VE). However, when VE wanes over time, estimates can become sensitive to study duration and timing of vaccine delivery relative to disease seasonality, and may be biased due to sample attrition. Additionally, estimates of vaccine impact such as number of cases averted (NCA) are sensitive to background disease incidence and timing of vaccine delivery.
View Article and Find Full Text PDFIsr J Health Policy Res
September 2025
Gray Faculty of Medical & Health Sciences, Tel Aviv University, Ramat Aviv, Israel.
Background: Prolonged shifts in residency contribute to physician fatigue, cognitive decline, and increased medical errors. This systematic review and meta-analysis evaluate how reducing shift length affects patient-physician safety, physician well-being, and residency training, addressing the ongoing challenge of balancing resident welfare, patient outcomes, and educational standards across varied implementation settings.
Methods: A comprehensive search of PubMed, EMBASE, The Cochrane Library, Google Scholar, and opengrey.
Trop Med Health
September 2025
World Health Organization Regional Office for the Western Pacific, Manila, Philippines.
Background: Tuberculosis preventive treatment (TPT) can avert progression from infection to disease, yet scale-up across the World Health Organization Western Pacific Region is patchy. To guide acceleration, we assessed progress, challenges and responses in seven high-burden countries-Cambodia, China, Lao People's Democratic Republic (PDR), Mongolia, Papua New Guinea, the Philippines and Viet Nam-drawing on 2015-2023 programme data, structured questionnaires, follow-up interviews and a regional validation workshop.
Main Body: Six of the seven countries have issued national TPT guidelines and five now offer shorter rifapentine- or rifampicin-based regimens.
Objective: Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) has been investigated clinically for treatment-resistant depression (TRD). Although the initial BROADEN study, a randomized controlled trial, was halted after an interim futility analysis, observation of long-term follow-up (LTFU) data from this and other cohorts demonstrated sustained improvement in depressive symptoms, prompting further investigation of DBS as a therapeutic option.
Methods: Data from 5 studies, including BROADEN, were used to evaluate the long-term safety and effectiveness of SCC DBS for TRD.