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http://dx.doi.org/10.2214/AJR.21.26626 | DOI Listing |
JAMA Netw Open
September 2025
Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock.
Importance: Patients with kidney failure (KF) receiving long-term dialysis have increased incidence of atrial fibrillation (AF). Patients with KF and AF have increased risk of stroke, death, and bleeding compared with age-matched cohorts. In KF, the use of oral anticoagulants (OACs) increases hemorrhage risk, offsetting potential benefits and making left atrial appendage occlusion (LAAO) a potentially promising solution for risk reduction in AF.
View Article and Find Full Text PDFJ Clin Endocrinol Metab
September 2025
Division of Intramural Research, National Library of Medicine, U.S. National Institutes of Health, Bethesda, Maryland, USA.
Background: Concerns about potential prostate-related complications associated with testosterone replacement therapy (TRT) often lead hypogonadal men to remain untreated.
Method: This large-scale retrospective cohort study aimed to address these concerns by analyzing Medicare enrollment and claims data (Parts A/B/C/D) from 2007 to 2020 for men aged ≥65 with diagnosed primary or secondary hypogonadism. Cox regression analysis and 1:1 propensity score matching, both stratified by age group, were employed to evaluate the association between prostate outcomes and TRT use.
Am J Prev Med
September 2025
Kaiser Permanente Northern California, Division of Research, Center for Addiction and Mental Health Research, Pleasanton, CA, United States.
Introduction: Prescription opioid dose reductions can raise the risk of adverse events for patients on long-term opioid therapy for non-cancer pain. Evidence on whether risks differ by age or sex is needed to support tailored clinical decision-making.
Methods: In 2024, a secondary analysis of an observational cohort study was conducted across 8 U.
Schizophr Res
September 2025
Columbia University and the New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, United States of America.
Purpose: Heterogeneity among people diagnosed with schizophrenia-spectrum disorders (schizophrenia) and high prevalence of co-occurring disorders makes identification of optimal treatments difficult. This study identified behavioral health phenotypes using machine learning with Medicaid claims of adults with schizophrenia. We compared the phenotypes' clinical outcomes and psychotropic medication prescription patterns for clinical validity.
View Article and Find Full Text PDFJ Forensic Sci
September 2025
School of Cybersecurity Korea University, Seoul, Korea.
Anti-forensics refers to techniques designed to obstruct the discovery of evidence in digital forensic investigations. File-wiping is one of the anti-forensic techniques that make data recovery impossible by overwriting data with specific patterns. This technique poses significant challenges to investigators.
View Article and Find Full Text PDF