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Ollier disease is a rare congenital pathology characterized by the growth of enchondromas in bones, accompanied with their deformities, fractures, and the risk of malignancy. A 39-year-old patient with Ollier disease (acroform with lesions of hands and feet) suffered a rapid development of osteomyelitis of the proximal phalanx of the ring finger after a mosquito bite. The condition localized in the area of enchondroma. Surgical treatment included osteonecrectomy in the phalanx and enchondroma with excision of non-viable surrounding soft tissues, drainage of the surgical wound and the imposition of primary sutures. Morphological analysis confirmed the presence of ectopic embryonic cartilage specific for Ollier disease and the bone destruction. The excised tissues were infiltrated with immune cells and had signs of periosteal chronic inflammation including fibrosis and hyalinosis. These changes, which occurred long before the mosquito bite, became a favorable background for the development of a purulent infection.
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http://dx.doi.org/10.3389/fsurg.2021.682101 | DOI Listing |
Clin Nucl Med
August 2025
Department of Nuclear Medicine, Faculty of Medicine, Selcuk University, Konya, Turkey.
First described by Ollier in 1899, Ollier disease is a rare, nonhereditary skeletal condition characterized by multiple enchondromas. Enchondromatosis can present bilaterally, often with a predominant side, and may manifest as monomelic or hemiskeletal involvement. Significant clinical challenges in Ollier disease include progressive limb shortening, angular deformities, and an elevated risk of pathologic fractures.
View Article and Find Full Text PDFWorld J Emerg Surg
July 2025
Department of Anesthesiology and Intensive Care Unit, Nord Hospital, Assistance Publique Hôpitaux Universitaires de Marseille, Marseille, 13015, France.
Purpose: Antimicrobial stewardship aims to improve clinical outcomes while reducing the unintended effects of antimicrobial use. The use of antibiotics in surgical wards, except for surgical antibiotic prophylaxis, has been poorly documented. Our goal was to assess the rate of compliance with the guidelines of antibiotic prescriptions in surgical wards.
View Article and Find Full Text PDFJMIR AI
June 2025
Key Laboratory of Advanced Design and Intelligent Computing, Dalian University, 10 Xuefu Street, Dalian, 116622, China, 86 041187402046.
Background: The mechanisms underlying the mutual relationships between chronic physical illnesses and mental health disorders, which potentially explain their association, remain unclear. Furthermore, how patterns of this comorbidity evolve over time are significantly underinvestigated.
Objective: The main aim of this study was to use machine learning models to model and analyze the complex interplay between mental health disorders and chronic physical illnesses.
Mol Ther
September 2025
AC Immune SA, 1015 Lausanne, Switzerland. Electronic address:
Transactive response DNA binding protein-43 (TDP-43)-mediated pathology is a hallmark of devastating neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Thus, monoclonal antibodies (mAbs) are being developed to target the pathological forms of this protein. To improve mAb exposure within the central nervous system, a potent anti-TDP-43 mAb, ACI-5891, was generated as a vectorized full-length antibody (vmAb) and evaluated for brain delivery using adeno-associated virus 9 (AAV9).
View Article and Find Full Text PDFInorg Chem
June 2025
Univ Brest, UMR CNRS 6521 CEMCA, 6 Avenue Victor le Gorgeu, 29238 Brest, France.
The development of Cu/Cu-based theranostic probes addresses the need for integrated cancer diagnosis and therapy. To target HER2-positive gastric cancer, trastuzumab was conjugated to (DOL of 1.1-2.
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