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http://dx.doi.org/10.1016/j.hbpd.2021.07.004 | DOI Listing |
Scand J Clin Lab Invest
September 2025
Department of Clinical Chemistry, HUS Diagnostic Center, University of Helsinki and Helsinki University Hospital, Finland.
Liver fibrosis is a common condition that potentially leads to cirrhosis, liver dysfunction, and hepatocellular carcinoma. The Enhanced Liver Fibrosis (ELF™) test is a validated tool for assessing fibrosis. The influence of preanalytical factors on ELF™ test has not been described in previous literature.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
Emergency Department, Shenzhen Longgang Second People's Hospital, Shenzhen, Guangdong Province, China.
Background: Compared to heparin, there is limited evidence of the benefits of bivalirudin in the patients with extracorporeal membrane oxygenation (ECMO).
Methods: We searched for studies comparing bivalirudin anticoagulation with heparin anticoagulation in ECMO patients in the PubMed, Embase, and Cochrane Library databases from inception to March 28, 2024. ECMO patients were divided into the bivalirudin experimental group and the heparin control group.
Sci Rep
August 2025
Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Burkholderia pseudomallei, the cause of melioidosis, forms biofilms that facilitate survival, alter antimicrobial susceptibility and promote disease recurrence. Neutrophils contribute to bacterial eradication through phagocytosis, degranulation and neutrophil extracellular traps (NETs). However, NETs are demonstrably insufficient to eradicate B.
View Article and Find Full Text PDFJ Thromb Haemost
July 2025
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA. Electronic address:
Background: Platelet factor 4 (PF4) plays a central role in heparin-induced thrombocytopenia (HIT). PF4 is a positively charged tetramer that forms immune complexes with anti-PF4 immunoglobulin G, activating platelets via FcγRIIA. Despite extensive study, a platelet receptor for PF4 within these complexes has not been clearly defined.
View Article and Find Full Text PDFPLoS Med
July 2025
Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
Background: Previous studies evaluating the influence of inter-hospital transfer on mortality in ST-segment elevation myocardial infarction (STEMI) patients undergoing primary percutaneous coronary intervention (PCI) reported conflicting results. The multicenter BRIGHT-4 trial demonstrated that bivalirudin plus a post-PCI high-dose infusion (1.75 mg/kg/h) reduced the 30-day primary endpoint of all-cause mortality or Bleeding Academic Research Consortium (BARC) types 3-5 bleeding compared with heparin monotherapy in STEMI patients.
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