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Urine is the best specimen for the diagnosis of congenital cytomegalovirus, but collection and processing of liquid urine are impractical for screening. Urine dried on filter paper was processed by the same convenient, low-cost method used by newborn screening to test blood spots and showed high sensitivity and specificity.
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http://dx.doi.org/10.1093/jpids/piab033 | DOI Listing |
Drug Test Anal
September 2025
Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.
Dried blood spots (DBS) have emerged as a promising complement, and in some settings, an alternative, to urine for anabolic androgenic steroid (AAS) testing, offering advantages such as minimal invasiveness, simplified storage, and transportation. This study evaluated two DBS collection devices-cellulose-based Capitainer-B50 and polymer-based Tasso-M20-and compared results with traditional urine analysis. Ten self-reported AAS users were recruited and provided matched urine and DBS samples.
View Article and Find Full Text PDFForensic Sci Int
August 2025
Department of Public Health, Experimental and Forensic Medicine, University of Pavia, via Forlanini, 12, Pavia 27100, Italy.
Dried urine spots (DUS) are emerging as a practical alternative to traditional urine collection in forensic and clinical toxicology, offering advantages in storage, handling, and biosafety. However, limited data exist on the stability of psychoactive substances in this matrix, particularly for opioids, synthetic cathinones, and dissociative anaesthetics. This study validates an LC-MS/MS method for the simultaneous quantification of twelve psychoactive drugs in DUS: methadone, EDDP, oxycodone, tapentadol, tramadol, ketamine, norketamine, fentanyl, carfentanyl, furanyl fentanyl, 3,4-MD-α-PHP, and MDPV.
View Article and Find Full Text PDFAnal Bioanal Chem
August 2025
National Institute of Pharmaceutical Education and Research-Ahmedabad (NIPER-A), An Institute of National Importance, Government of India, Palaj, Gandhinagar, 382355, Gujarat, India.
Urine samples are gaining increasing importance as preferred biological matrices in bioanalytical studies due to their non-invasive collection, abundance, and ability to reflect systemic metabolism. However, conventional urine sampling and storage methods face significant challenges, especially in resource-limited areas where transportation and preservation infrastructure are inadequate. Traditional methods of liquid urine collection require refrigeration to prevent analyte degradation, making long-term storage and global sample transport costly and impractical.
View Article and Find Full Text PDFAntioxidants (Basel)
August 2025
Research Group on Community Nutrition & Oxidative Stress, University of Balearic Islands-IUNICS, IDISBA & CIBEROBN, Guillem Colom Bldg, Campus, 07122 Palma de Mallorca, Spain.
: To assess oxidative-inflammatory biomarker prediction of incident CKD after 1-year follow-up in a population with overweight/obesity and metabolic syndrome. : Prospective nested case-control study comprising 117 CKD incident cases and 117 matched controls free of CKD after 1-year follow-up conducted in 55-75-year-old participants. Controls were time-matched 1:1 to cases by intervention group, age (≤65 vs.
View Article and Find Full Text PDFInt J STD AIDS
August 2025
Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
BackgroundRates of sexually transmitted and blood borne infections (STBBI) are rapidly increasing. Despite the high diagnostic accuracy of self-testing, no fully remote STBBI testing programs are available in Canada. We aimed to evaluate the feasibility and acceptability of a fully-remote, web-based, at-home STBBI testing (self-collection) program in Calgary, Canada.
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