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http://dx.doi.org/10.1002/pbc.29278 | DOI Listing |
J Org Chem
September 2025
Pharmaron Drug Discovery Services Europe, Pharmaron UK Ltd., West Hill Innovation Park, Hertford Road, Hoddesdon EN11 9FH, United Kingdom.
Sulfur(VI) fluoride exchange (SuFEx) compounds are gaining increasing attention due to their various applications. We present the Diels-Alder reaction of ethenesulfonyl fluoride and analogues to rapidly access cyclic and bicyclic SuFEx derivatives in moderate to good yields. These derivatives have been shown to be useful intermediates in a variety of synthetic transformations to expand the toolkit for the preparation of cyclic aliphatic sulfonyl fluorides.
View Article and Find Full Text PDFArch Pharm (Weinheim)
September 2025
Department of Biology, Faculty of Arts and Sciences, Cukurova University, Adana, Turkey.
l-Ascorbic acid exhibits paradoxical behavior as both antioxidant and pro-oxidant in cancer treatment, with mechanisms and optimal dosing remaining unclear. This in vitro study investigated l-ascorbic acid's effects on healthy lymphocytes and HL-60 leukemia cells using concentrations of 0.5-2 mg/mL for 6 and 24 h.
View Article and Find Full Text PDFJ Med Ethics
September 2025
Shrewsbury Public Schools, Shrewsbury, Massachusetts, USA
The integration of artificial intelligence (AI) into pharmaceutical practices raises critical ethical concerns, including algorithmic bias, data commodification and global health inequities. While existing AI ethics frameworks emphasise transparency and fairness, they often overlook structural vulnerabilities tied to race, gender and socioeconomic status. This paper introduces relational accountability-a feminist ethics framework-to critique AI-driven pharmaceutical practices, arguing that corporate reliance on biased algorithms exacerbates inequalities by design.
View Article and Find Full Text PDFJACC Cardiovasc Interv
September 2025
Division of Vascular Surgery, Department of Surgery, the Jikei University School of Medicine, Tokyo, Japan.
Background: Long-term comparative data on drug-eluting stents (DES) and drug-coated balloons (DCB) for femoropopliteal artery (FPA) disease remain limited.
Objectives: The authors sought to compare 3-year outcomes of DES vs DCB without bailout stenting in FPA disease.
Methods: We retrospectively analyzed 1,406 patients from a multicenter registry who underwent endovascular therapy for FPA using DES (n = 342) or DCB (n = 1,064) after the successful lesion preparation.
BMJ Open
September 2025
Pharmacy Department, St John of God University Hospital, Dublin, Ireland.
Objectives: To address the lack of accurate and accessible mental health medicines-information resources for children, young people and their parents/guardians using design thinking to co-design free-to-use, video resources tailored to this audience.
Design: A multiphase qualitative case study using the Double Diamond model of Design Thinking: Discover, Define, Develop and Deliver. This included iterative prototyping, thematic analysis and public and patient involvement throughout.