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Article Abstract
Seven new tropane alkaloids, including five monomeric (-), one dimeric (), and one trimeric () 3α-nortropane ester, along with two known monomeric nortropane alkaloids ( and ), were isolated from the leaves and bark of . Their structures, including the absolute configuration of the enantiomeric pair of (±)-, were elucidated by comprehensive spectroscopic analyses. Alkaloids and showed cytotoxicity toward human pancreatic cancer cell lines (AsPC-1, BxPC3, PANC-1, and SW1990). Alkaloids , , and induced a smooth muscle relaxation effect comparable to that of atropine ( 106.1 ± 7.5%, 97.0 ± 5.2%, 100.9 ± 1.4%, 111.7 ± 1.7%, respectively) on isolated rat tracheal rings.
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