Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: India has set a goal to eliminate measles and rubella/Congenital Rubella Syndrome (CRS) by 2023. Towards this goal, India conducted nationwide supplementary immunization activity (SIA) with measles-rubella containing vaccine (MRCV) targeting children aged between 9 months to <15 years and established a hospital-based sentinel surveillance for CRS. Reliable data about incidence of CRS is necessary to monitor progress towards the elimination goal.
Methods: We conducted serosurveys in 2019-20 among pregnant women attending antenatal clinics of 6 hospitals, which were also sentinel sites for CRS surveillance, to estimate the prevalence of IgG antibodies against rubella. We systematically sampled 1800 women attending antenatal clinics and tested their sera for IgG antibodies against rubella. We used rubella seroprevalence data from the current survey and the survey conducted in 2017 among antenatal women from another 6 CRS surveillance sites to construct a catalytic models to estimate the incidence and burden of CRS.
Result: The seroprevalence of rubella antibodies was 82.3% (95% CI: 80.4-84.0). Rubella seropositivity did not differ by age group and educational status. Based on the constant and age-dependent force of infection models, we estimated that the annual incidence of CRS in India was 225.58 per 100,000 live births (95% CI: 217.49-232.41) and 65.47 per 100,000 live births (95% CI: 41.60-104.16) respectively. This translated to an estimated 14,520 (95% CI: 9,225-23,100) and 50,028 (95% CI: 48,234-51,543) infants with CRS every year based on age-dependent and constant force of infection models respectively.
Conclusions: Our findings indicated that about one fifth of women in the reproductive age group in India were susceptible for rubella. The estimates of CRS incidence will serve as a baseline to monitor the impact of MRCV SIAs, as well progress towards the elimination goal of rubella/CRS.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8376255 | PMC |
| http://dx.doi.org/10.1371/journal.pntd.0009608 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Deceptive appearances: Congenital infections simulating genetic syndromes in fetal Pathology.
J Neonatal Perinatal Med
August 2025
Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bibinagar, Hyderabad.
Transplacental infections such as cytomegalovirus, Zika virus, toxoplasmosis, and rubella, especially if acquired in the perinatal period, are well-known causes of congenital anomalies. However, their phenotypic overlap with certain genetic syndromes can pose significant diagnostic challenges during fetal autopsy and prenatal counseling. With an objective to review and highlight the clinical and pathological similarities between congenital infections and genetic syndromes, and emphasizing diagnostic pitfalls in fetal autopsy and the importance of integrated approaches, a comprehensive literature review was performed of articles that discussed congenital infections, fetal autopsy findings, and differential diagnosis with genetic syndromes.
View Article and Find Full Text PDFNatural Language Processing applied to electronic records: surveillance and detection of health events.
Cien Saude Colet
July 2025
Secretaria Municipal de Saúde do Município do Rio de Janeiro. R. Afonso Cavalcanti 455, 7º andar, Cidade Nova. 20211-110 Rio de Janeiro RJ Brasil.
Text fields in medical records are a valuable source for Public Health Surveillance but remain underutilized. This study describes the use of natural language processing (NLP) to enhance the identification of suspected cases and monitor disease trends in electronic records from the Urgency and Emergency Network (Rede de Urgência e Emergência - RUE), in the municipality of Rio de Janeiro (MRJ). Texts were pre-processed, and rules were applied to identify individual (measles and rubella) and collective (diarrhea and influenza-like syndrome) events, comparing the results with ICD-10 data from January 2023 to September 2024.
View Article and Find Full Text PDFDandy-Walker spectrum with bilateral optic atrophy and seizure disorder: a case report and literature review.
Ann Med Surg (Lond)
August 2025
Department of Pediatrics and Adolescents Medicine, B.P. Koirala Institute of Health Sciences, Dharan, Sunsari, Nepal.
Introduction And Importance: Dandy-Walker syndrome (DWS) is a rare congenital posterior fossa malformation, affecting 1 in 25 000-30 000 live births. Prenatal diagnosis is possible via ultrasound and MRI. This case highlights a rare Dandy-Walker variant with bilateral optic atrophy and status epilepticus, emphasizing the need for awareness of progressive neurological and visual impairment in Dandy-Walker spectrum disorders.
View Article and Find Full Text PDFLong-term impact of oral cladribine on humoral immunity in multiple sclerosis.
Ther Adv Neurol Disord
August 2025
Department of Neurology, Neurocritical Care, and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University and Center for Cognitive Neuroscience, member of European Reference Network EpiCARE, Ignaz-Harrer-Straße 79, Salzburg 5020, Austria.
Background: Cladribine (CLAD), an immune reconstitution therapy for active multiple sclerosis (MS), can reduce intrathecal antibody production.
Objectives: In this study, we investigated the long-term impact of oral CLAD on protective antibody levels, essential for preventing infections and immune defense.
Design: Observational long-term study including a cohort of 15 CLAD-treated MS patients.