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http://dx.doi.org/10.6705/j.jacme.202106_11(2).0006 | DOI Listing |
Alzheimers Dement (Amst)
September 2025
Introduction: Simple screening tools are critical for assessing Alzheimer's disease (AD)-related pre-dementia changes. This study investigated longitudinal scores from the Quick Dementia Rating System (QDRS), a brief study partner-reported measure, in relation to baseline levels of the AD biomarker plasma pTau217 in individuals unimpaired at baseline.
Methods: Data from the Wisconsin Registry for Alzheimer's Prevention (N = 639) were used to examine whether baseline plasma pTau217 (ALZpath assay on Quanterix platform) modified QDRS or Preclinical Alzheimer's Cognitive Composite (PACC3) trajectories (mixed-effects models; time = age).
Cureus
August 2025
Department of Cardiology, Pulmonology, Hypertension, and Nephrology, Ehime University Graduate School of Medicine, Toon, JPN.
Objectives In Japan, clinical diagnosis based solely on symptoms, without the use of test kits, has been adopted to enable the rapid identification of individuals infected with coronavirus disease 2019 (COVID-19). A history of close contact with COVID-19 patients is a prerequisite for such symptom-based diagnosis. However, the current diagnostic criteria lack objectivity.
View Article and Find Full Text PDFCureus
August 2025
Department of Rheumatology and Bone Diseases, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, CHN.
Background: There is growing evidence that Sjögren's syndrome (SS) and atherosclerosis (AS) might share underlying immunological and inflammatory processes. Observational data have pointed toward a potential association between SS and a heightened likelihood of developing AS, though the causal direction and specific dynamics of this relationship have not been clearly verified. This Mendelian randomization (MR) investigation opts to investigate potential bidirectional causality between SS and three types of AS: coronary, cerebral, and peripheral.
View Article and Find Full Text PDFJ Cardiovasc Electrophysiol
September 2025
Cardiac Electrophysiology Section, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
Introduction: Iatrogenic lead perforation is a rare but serious complication of cardiac implantable electronic device (CIED) implantation. Evidence on percutaneous management of subacute or delayed cases remains limited.
Methods: We retrospectively reviewed 38 patients treated for iatrogenic lead perforation between January 2012 and October 2024.
Encephale
September 2025
Département de psychiatrie de l'adolescent et du jeune adulte, institut mutualiste Montsouris, 42, boulevard Jourdan, Paris, France; UVSQ, Inserm U1178, PsyDev, CESP université Paris-Saclay, Villejuif, France; Université Paris-Cité, Paris, France.
The body of knowledge on trauma is rapidly expanding. Since 2022, the WHO has been calling for the history of adversity to be systematically taken into account when assessing the state of health of all individuals. But at this stage, our understanding of the precise mechanisms of complex trauma remains incomplete.
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