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Concerns are often raised about the impact that playing video games may have on cognition and behavior, whether gameplay is intense and protracted as with competitive Esports or whether it is more casual gameplay. Work in our lab and others, however, has shown that at least some classes of games can improve memory function. In particular, playing immersive 3D games that provide rich experiences and novelty improve memory on tasks that rely upon the hippocampus in effects that mirror the effects of "environmental enrichment" in numerous rodent studies. Our goal in the present study was to determine whether even modest amounts of gameplay (~30 min/day for 4 weeks) would result in improved memory performance in middle-aged adults. Not only is this demographic potentially highly receptive to gaming (they make up a significant portion of Esports viewers and of game players), but interventions in middle age may be a prime time for reducing later age-related cognitive decline. Here, we found that the benefits in middle age paralleled effects previously observed in young adults as playing , showing improved memory performance on a hippocampal dependent memory task.
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http://dx.doi.org/10.3389/fspor.2021.685286 | DOI Listing |
PLoS Comput Biol
September 2025
Sussex Neuroscience, School of Life Sciences, University of Sussex, Brighton, United Kingdom.
Individually foraging ants use egocentric views as a dominant navigation strategy for learning and retracing routes. Evidence suggests that route retracing can be achieved by algorithms which use views as 'visual compasses', where individuals choose the heading that leads to the most familiar visual scene when compared to route memories. However, such a mechanism does not naturally lead to route approach, and alternative strategies are required to enable convergence when off-route and for correcting on-route divergence.
View Article and Find Full Text PDFGerontologist
September 2025
Neuropsychology and Cognitive Health Program, Baycrest Hospital, Toronto, Ontario, Canada.
Background And Objectives: As they age, many people experience memory changes that can impact their everyday functioning. The Memory Impact Questionnaire (MIQ) is a 51-item measure that assesses the negative impact of memory changes on one's lifestyle activities, negative appraisals of the self due to memory changes, perceived negative appraisals from others due to memory changes, and coping approaches intended to compensate for memory changes. To improve the utility of this tool, we developed a short form version of the MIQ and investigated its psychometric properties.
View Article and Find Full Text PDFIEEE J Biomed Health Inform
September 2025
Epilepsy, a highly individualized neurological disorder, affects millions globally. Electroencephalography (EEG) remains the cornerstone for seizure diagnosis, yet manual interpretation is labor-intensive and often unreliable due to the complexity of multi-channel, high-dimensional data. Traditional machine learning models often struggle with overfitting and fail in fully capturing the highdimensional, temporal dynamics of EEG signals, restricting their clinical utility.
View Article and Find Full Text PDFNeurochem Res
September 2025
Biology and Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.
Parkinson's disease (PD) is characterized by impairments in motor control following the degeneration of dopamine-producing neurons located in the substantia nigra pars compacta. Environmental pesticides such as Paraquat (PQ) and Maneb (MB) contribute to the onset of PD by inducing oxidative stress (OS). This study evaluated the therapeutic efficacy of moderate physical activity (PA) on both motor and non-motor symptoms in a Wistar rat model of Paraquat and Maneb (PQ/MB) induced PD.
View Article and Find Full Text PDFElife
September 2025
Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, United States.
Fragile X syndrome (FXS), a leading inherited cause of intellectual disability and autism, is frequently accompanied by sleep and circadian rhythm disturbances. In this study, we comprehensively characterized these disruptions and evaluated the therapeutic potential of a circadian-based intervention in the fragile X mental retardation 1 () knockout (KO) mouse. The KO mice exhibited fragmented sleep, impaired locomotor rhythmicity, and attenuated behavioral responses to light, linked to an abnormal retinal innervation and reduction of light-evoked neuronal activation in the suprachiasmatic nucleus.
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