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Objective: To determine the incidence of adverse events (AEs) associated with umbilical catheters in the neonatal population.
Study Design: Systematic review and meta-analysis of observational studies and randomized controlled trials published between 2010 and 2020.
Results: In total 14,226 umbilical venous catheters (UVCs) and 4228 umbilical arterial catheters (UACs) were included. Overall, 13.4% of UVCs were associated with an AE (95% CI: 10.1-17.0) or 2.4 per 1000 catheter days (95% CI: 1.8-3.0). UACs had an AE rate of 9% (95% CI: 5.9-12.8) or 0.87 per 1000 catheter days (95% CI: 0.4-1.3). UVC malposition was the most common (41.7% [95% CI: 27.6-56.5]). Local injury from UAC taping was the most common AE in one study.
Conclusions: Umbilical catheters have a high incidence of AEs. Research into accurate methods of tip verification, tip surveillance, and securement is required.
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http://dx.doi.org/10.1038/s41372-021-01147-x | DOI Listing |
Turk J Pediatr
September 2025
Department of Anesthesiology, All India Institute of Medical Sciences, Patna, India.
Background: Umbilical arterial catheterisation is a common intervention performed in the neonatal intensive care unit (NICU) especially in extremely preterm and extremely low birth weight neonates. Rarely catheter fracture or breakage can occur, leaving behind part of the catheter in the aorta. A handful of cases have been reported in the literature, with the majority being managed surgically.
View Article and Find Full Text PDFCureus
August 2025
Anesthesiology, Om Prakash (OP) Jindal Institute of Medical Sciences, Hisar, IND.
Congenital diaphragmatic hernia (CDH) is a serious congenital anomaly often associated with pulmonary hypoplasia and persistent pulmonary hypertension of the newborn (PPHN). Central vascular access such as umbilical arterial catheters (UACs) is routinely used in neonatal intensive care but is associated with the risk of vascular complications, including thromboembolic events. We present a case of preterm dichorionic diamniotic (DCDA) twins born at 34 weeks of gestation with antenatally diagnosed CDH.
View Article and Find Full Text PDFActa Paediatr
September 2025
Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Department of Pediatrics, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, Austria.
Aim: Successful procedural performance in a Neonatal Intensive Care Unit (NICU) depends on skill performance and preparation. Checklists are beneficial, and video reviewing enhances adherence to guidelines. This study assessed whether video recordings can be used to assess checklist deviations, the extent to which proceduralists (doctors from 1 to ≥ 6 years of experience) deviate from checklists, and whether video recordings can help to improve existing and create new checklists.
View Article and Find Full Text PDFStem Cell Res Ther
September 2025
Department for Small Animals and Horses, Centre for Equine Health and Research, Equine Surgery Unit, Veterinary Tissue Engineering and Regenerative Medicine Laboratory, University of Veterinary Medicine Vienna, Vienna, Austria.
Background: Osteoarthritis (OA) remains an intractable condition due to the limited regenerative capacity of adult cartilage. Extracellular vesicles (EVs) have emerged as promising therapeutics, yet the optimal donor cell source is still undetermined, as both donor cell type and age significantly influence EV therapeutic efficacy. This study evaluates the therapeutic potential of EVs derived from ovine fetal articular chondrocytes (fCCs) and ovine fetal umbilical cord blood mesenchymal stromal cells (fMSCs) compared to EVs from two immortalized human perinatal cell lines, Wharton's jelly (WJ-MSCs) and amnion MSCs (P-MSCs), on inflamed ovine adult chondrocytes and synoviocytes in vitro.
View Article and Find Full Text PDFJ Perinatol
August 2025
Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Children Hospital at Montefiore Einstein, Bronx, NY, USA.
Objective: Umbilical artery catheters (UAC) are common in the neonatal intensive care unit. Catheters are often re-adjusted and require multiple X-rays. Point of care ultrasound (POCUS) is reliable and safe.
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