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Three-dimensional (3D) imaging is increasingly being incorporated into a variety of medical specialties: surgery and radiology being but two prominent examples. Image-intensive disciplines, such as anatomic pathology (AP), represent excellent potential candidates for further exploration of this innovative technology. Multiple potential use cases exist within AP, involving patient care, education, and research. These use cases broadly include direct utilization of the 3D digital assets for viewing on a 2D screen, populating 3D extended reality platforms (virtual reality, augmented reality, and mixed reality) as well as generation of 3D printed photorealistic specimen models. Herein, these use cases are explored with specific regard to our experiences and yet unrealized potential. Future directions and considerations are also discussed.
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http://dx.doi.org/10.4103/jpi.jpi_8_21 | DOI Listing |
Cureus
August 2025
Histology and Embryology, David Tvildiani Medical University, Tbilisi, GEO.
This case report is focused on a patient (a 32-year-old previously healthy man) with a femoral bone tissue tumor. The case underscores the diagnostic complexity of Telangiectatic Osteosarcoma (TOS) with Aneurysmal Bone Cystic (ABC) lesion and the importance of maintaining special immunohistochemical markers for differential diagnosis between low-grade osteosarcoma, primary ABC, and suspected TOS, which is a true mimicker of ABC. On the other hand, this presentation describes some molecular rearrangements seen in ABC.
View Article and Find Full Text PDFCase Rep Genet
September 2025
Division of Maternal-Fetal Medicine, Department of Obstetrics & Gynecology, University of California, Irvine, California, USA.
Nonimmune hydrops fetalis (NIHF) refers to the pathologic accumulation of fluid within the fetus due to causes other than red cell alloimmunization and now accounts for up to 90% of fetal hydrops cases. Fetal hydrops is associated with significant morbidity and mortality, and the exact prognosis is largely dependent on the underlying etiology. The most common etiologies include cardiovascular causes and chromosomal or genetic abnormalities.
View Article and Find Full Text PDFVirchows Arch
September 2025
Department of Anatomic Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Lung adenocarcinoma (LUAD) associated with usual interstitial pneumonia (UIP) harbours distinct features compared to lung adenocarcinoma without UIP. Therefore, we aimed to characterise the tumour microenvironment of LUAD with UIP by focusing on cancer-associated fibroblasts (CAFs) and stromal composition. Immunohistochemistry was performed on 32 LUAD samples (16 each with and without UIP) to evaluate CAF marker expression and lymphocyte infiltration.
View Article and Find Full Text PDFActa Neuropathol
September 2025
Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.
Abdom Radiol (NY)
September 2025
Johns Hopkins University, Baltimore, United States.
Vulvar anatomy and pathology can be a challenging subject to master, especially given the paucity of resources available on the subject. This review provides an overview of normal anatomy and imaging appearance of the vulva, including the mons pubis, labia majora, labia minora, clitoris, clitoral hood, external urethral meatus, vestibule and vaginal introitus, the Bartholin (greater vestibular) glands and the Skene (lesser vestibular or paraurethral) glands. We will also review the imaging appearance of various benign and malignant pathologies that affect these structures, including congenital adrenal hyperplasia, vulvar cancers, benign cysts, and urethral diverticula, with an emphasis on MR imaging.
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