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Brugada syndrome (BrS) is a rare, genetically predisposed arrhythmic disorder associated with an elevated risk of sudden cardiac death (SCD) due to ventricular arrhythmias. Fever is a recognized trigger that can unmask the Type 1 Brugada electrocardiogram (ECG) pattern and precipitate life-threatening arrhythmias, even in individuals without prior cardiac symptoms. A 38-year-old male with no known cardiac history presented with fever, palpitations, and dizziness.
View Article and Find Full Text PDFLong-term prognosis of patients with an SCN5A loss-of-function variant and progressive cardiac conduction disorder or Brugada syndrome.
Heart Rhythm
May 2025
Department of Clinical Cardiology, Heart Center, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands; European Reference Network for rare, low prevalence, and complex diseases of the heart (ERN GUARD-Heart), Amsterdam, The Netherlands. Electronic address: a.s.am
Background: The long-term prognosis of patients with a loss-of-function variant in the cardiac sodium channel gene SCN5A is unknown.
Objective: This study aimed to evaluate the long-term arrhythmic risk in patients with an SCN5A loss-of-function variant to identify predictors of arrhythmic events.
Methods: Probands and family members with (likely) pathogenic SCN5A loss-of-function variants were retrospectively included.
Identification of a Novel gene variant in a young female with atrioventricular canal defect in the absence of classical Brugada syndrome phenotype.
Med Res Arch
August 2024
Institute of Neuroscience, University of Kolkata, India.
Article Synopsis
- Brugada syndrome is a heart condition linked to sudden cardiac events, primarily caused by mutations in the sodium channel gene, SCN5A.
- A case study involved a 25-year-old woman with a heart defect who tested positive for a new variant of the SCN5A gene, despite having no prior symptoms or family history of the syndrome.
- The findings suggest that this new gene variant could have harmful impacts, further emphasizing the importance of genetic screening in asymptomatic individuals.
Deceptive Anteroseptal ST-segment Elevation and Brugada Pattern Caused by Isolated Conus Artery Occlusion.
Arq Bras Cardiol
June 2024
Izmir Tepecik Training and Research Hospital - Department of Cardiology, Konak, İzmir - Turquia.
The conus artery (CA) supplies the right ventricular outflow tract (RVOT). ST-segment elevation in leads V1-3, which can resemble Brugada electrocardiogram (EKG) patterns, has been reported due to occlusion of the CA. A 68-year-old male was admitted to the hospital with a diagnosis of non-ST-elevation myocardial infarction.
View Article and Find Full Text PDFMolecular Autopsy With Banked Cord Blood Reveals Brugada Syndrome in Past Sudden Death Case.
Pediatrics
May 2024
Department of Bioscience and Genetics, National Cerebral and Cardiovascular Center Research Institute, Suita, Japan.
Molecular autopsy has recently been gaining attention as a means of postmortem diagnosis; however, it is usually performed using the victim's blood sample at the time of death. Here, we report the first case of a deceased infant with Brugada syndrome whose diagnosis was made with banked cord blood. A seemingly healthy 1-year-old male infant collapsed while having a fever; this collapse was witnessed by his mother.
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