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http://dx.doi.org/10.1038/s41586-021-03655-4 | DOI Listing |
Front Oncol
August 2025
Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.
Objective: The risk of lymph node metastasis significantly influences the choice of surgical strategy for patients with early-stage endometrial cancer. While sentinel lymph node dissection can be considered in clinically early-stage endometrial cancer, lymph node evaluation might be omitted in patients with very low risk of lymph node metastasis. This study aims to develop a predicting model for lymph node metastasis in these patients, identifying potential metastases as thoroughly as possible to provide clinicians with a preoperative reference that helps in decisions about surgical procedures and treatments.
View Article and Find Full Text PDFMed Phys
September 2025
Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Background: Four-dimensional magnetic resonance imaging (4D-MRI) holds great promise for precise abdominal radiotherapy guidance. However, current 4D-MRI methods are limited by an inherent trade-off between spatial and temporal resolutions, resulting in compromised image quality characterized by low spatial resolution and significant motion artifacts, hindering clinical implementation. Despite recent advancements, existing methods inadequately exploit redundant frame information and struggle to restore structural details from highly undersampled acquisitions.
View Article and Find Full Text PDFWomens Health Issues
September 2025
Tufts University School of Medicine/Tufts Medicine, Boston, Massachusetts. Electronic address:
Background: More than 20% of cervical cancers are diagnosed in women older than 65 years. Guidelines recommend screening exit at age 65 for average-risk patients only if certain criteria are met, yet most women aged 64-66 years in the United States are inadequately screened. In this mixed methods study, we explored clinician knowledge of exit criteria.
View Article and Find Full Text PDFZhonghua Jie He He Hu Xi Za Zhi
September 2025
Neuromuscular diseases are often accompanied by various types of sleep-related breathing disorders, which can exacerbate the underlying condition and are associated with a poor prognosis. Early identification is essential, and interventions such as non-invasive ventilation, oxygen therapy, and respiratory rehabilitation should be initiated promptly to mitigate disease progression and improve outcomes. Nevertheless, the rates of missed and misdiagnosed cases remain common in clinical practice.
View Article and Find Full Text PDFDrug Test Anal
September 2025
Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden.
Dried blood spots (DBS) have emerged as a promising complement, and in some settings, an alternative, to urine for anabolic androgenic steroid (AAS) testing, offering advantages such as minimal invasiveness, simplified storage, and transportation. This study evaluated two DBS collection devices-cellulose-based Capitainer-B50 and polymer-based Tasso-M20-and compared results with traditional urine analysis. Ten self-reported AAS users were recruited and provided matched urine and DBS samples.
View Article and Find Full Text PDF