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Article Abstract
Histone deacetylase enzymes (HDACs) are potential targets for the treatment of cancer and other diseases, but it is challenging to design isoform-selective agents. In this work, we created new analogs of two established but non-selective HDAC inhibitors. We decorated the central linker chains of the molecules with specifically positioned fluorine atoms in order to control the molecular conformations. The fluorinated analogs were screened against a panel of 11 HDAC isoforms, and minor differences in isoform selectivity patterns were observed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8271401 | PMC |
| http://dx.doi.org/10.3390/molecules26133974 | DOI Listing |
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