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Coccidioidomycosis is an infectious disease of humans and other mammals that has seen a recent increase in occurrence in the southwestern United States, particularly in California. A rise in cases and risk to public health can serve as the impetus to apply newly developed methods that can quickly and accurately predict future caseloads. The recursive and Hawkes point process models with various triggering functions were fit to the data and their goodness of fit evaluated and compared. Although the point process models were largely similar in their fit to the data, the recursive point process model offered a slightly superior fit. We explored forecasting the spread of coccidioidomycosis in California from December 2002 to December 2017 using this recursive model, and we separated the training and testing portions of the data and achieved a root mean squared error of just 3.62 cases/week.
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http://dx.doi.org/10.3390/idr13020052 | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
Institut de Biologie de l'Ecole Normale Supérieure, Ecole Normale Supérieure, Université Paris Sciences et Lettres, Centre National de la Recherche Scientifique, Institut National de la Santé et de la Recherche Médicale, Paris 75005, France.
Excitatory glycine receptors (eGlyRs), composed of the glycine-binding NMDA receptor subunits GluN1 and GluN3A, have recently emerged as a novel neuronal signaling modality that challenges the traditional view of glycine as an inhibitory neurotransmitter. Unlike conventional GluN1/GluN2 NMDARs, the distribution and role of eGlyRs remain poorly understood. Here, we show that eGlyRs are highly enriched in the ventral hippocampus (VH) and confer distinct properties on this brain region.
View Article and Find Full Text PDFJ Strength Cond Res
September 2025
Institute for Data Analysis and Process Design, ZHAW, Zurich, Switzerland; and.
Achermann, BB, Drewek, A, and Lorenzetti, SR. Acute effect of the bounce squat on ground reaction force at the turning point and barbell kinematics. J Strength Cond Res XX(X): 000-000, 2025-The free-weight back squat is a key exercise for developing lower-body strength, with variations that influence muscle activation and performance.
View Article and Find Full Text PDFJ Neurooncol
September 2025
Department of Neurosurgery, University of Michigan, Ann Arbor, MI, USA.
Purpose: Frailty measures are critical for predicting outcomes in metastatic spine disease (MSD) patients. This study aimed to evaluate frailty measures throughout the disease process.
Methods: This retrospective analysis measured frailty in MSD patients at multiple time points using a modified Metastatic Spinal Tumor Frailty Index (MSTFI).
Psychol Res
September 2025
Berlin School of Mind and Brain & Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany.
The existence of free will has been called into question by Benjamin Libet's seminal experiment, who argued that our conscious decision is preceded by an unconscious decision reflected in the readiness potential (RP). Alternatively, it has been argue that the RP rather reflects a decision process in which different signals accumulate until they reach the intention threshold, at which point an agent experience their intention simultaneously. This raises the question what type of signal is accumulated given that no external information is provided.
View Article and Find Full Text PDFEur J Clin Pharmacol
September 2025
Department of Hospital Pharmacy, Meander Medical Centre, Amersfoort, the Netherlands.
Purpose: This study was designed to analyse the influence of temperature, pH and storage time on unbound fractions of PHT and VPA.
Methods: The influence of ultrafiltration (UF) temperature on measured unbound fractions of PHT and VPA in spiked samples was evaluated in a single laboratory experiment and in data from a national external quality control (EQC) database. The influence of pH adjustment with phosphate buffered saline (PBS) on measured unbound fractions of PHT and VPA was investigated in patient samples.