Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.17843/rpmesp.2021.381.5487 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The role of Denisovan paleohabitats in shaping modern human genetic resistance to viral, bacterial, and parasitic infections.
J Hum Evol
September 2025
Sustainability Solutions Research Lab, University of Pannonia, Egyetem utca 10, H-8200, Veszprém, Hungary. Electronic address:
Denisovans contributed notably to the genomes of present-day East and Southeast Asians. However, the relationship between the inhabited paleohabitats and the adaptive genetic traits related to infections in modern humans remains underexplored. This study uses geospatial techniques to analyze climatic factors associated with three Denisovan archaeological sites linked to nine specimens.
View Article and Find Full Text PDFMevalonate kinase deficiency in a familial Mediterranean fever endemic region: a single-center experience.
Turk J Pediatr
September 2025
Division of Pediatric Rheumatology, Department of Pediatrics, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Türkiye.
Background: We aimed to document childhood onset mevalonate kinase deficiency (MKD) and to explore treatment responses and diagnostic challenges in regions endemic to familial Mediterranean fever (FMF).
Methods: This retrospective study included patients under 18 years of age, diagnosed with MKD and followed for at least six months at the pediatric rheumatology department of Istanbul University - Cerrahpaşa Medical Faculty between 2016 and 2024.
Results: Of 33 patients, 51.
Cathepsin Z is a conserved susceptibility factor underlying tuberculosis severity.
PLoS Biol
September 2025
Department of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States of America.
Tuberculosis (TB) outcomes vary widely, from asymptomatic infection to mortality, yet most animal models do not recapitulate human phenotypic and genotypic variation. The genetically diverse Collaborative Cross mouse panel models distinct facets of TB disease that occur in humans and allows identification of genomic loci underlying clinical outcomes. We previously mapped a TB susceptibility locus on mouse chromosome 2.
View Article and Find Full Text PDFThe Salmonella phage shock protein system is required for defense against host antimicrobial peptides.
PLoS Pathog
September 2025
Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.
Macrophages are professional phagocytes that play a major role in engulfing and eliminating invading pathogens. Some intracellular pathogens, such as Salmonella enterica serovar Typhimurium, exploit macrophages as niches for their replication, which requires precise and dynamic modulation of bacterial gene expression in order to resist the hostile intracellular environment. Here, we present a comprehensive analysis of the global transcriptome of S.
View Article and Find Full Text PDFDiversity and spread of cytoplasmic incompatibility genes among maternally inherited symbionts.
PLoS Genet
September 2025
MIVEGEC, University of Montpellier, CNRS, IRD, Montpellier, France.
Cytoplasmic Incompatibility (CI) causes embryonic lethality in arthropods, resulting in a significant reduction in reproductive success. In most cases, this reproductive failure is driven by Wolbachia endosymbionts through their cifA/cifB gene pair, whose products disrupts arthropod DNA replication during embryogenesis. While a cif pair has been considered a hallmark of Wolbachia, its presence and functional significance in other bacterial lineages remains poorly investigated.
View Article and Find Full Text PDF