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Article Abstract
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8242300 | PMC |
| http://dx.doi.org/10.3988/jcn.2021.17.3.496 | DOI Listing |
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First reported case of thymoma-associated multiorgan autoimmunity induced by COVID-19.
J Dermatol
December 2024
Department of Dermatology, Tokyo Medical University, Tokyo, Japan.
Article Synopsis
- - Thymoma-associated multiorgan autoimmunity (TAMA) involves symptoms like skin issues, liver dysfunction, and enteritis, similar to graft-versus-host disease (GVHD), but occurs without prior stem cell or bone marrow transplants and is linked to thymoma.
- - A 64-year-old woman with myasthenia gravis and thymoma developed skin rashes after a COVID-19 infection, initially suspected to be a drug reaction, but despite treatment adjustments, her condition worsened and led to severe gastrointestinal symptoms.
- - The patient's diagnosis of TAMA was confirmed through skin biopsy showing GVHD-like changes, and her decline included complications from infections, ultimately resulting in her death, with COVID-
Thymoma-Associated Multiorgan Autoimmunity (TAMA) Presenting as a Graft Versus Host Disease-Like Erythroderma.
J Cutan Pathol
January 2025
Department of Dermatology, West Virginia University School of Medicine, Morgantown, West Virginia, USA.
Thymoma-associated multiorgan autoimmunity (TAMA) is a rare paraneoplastic disorder that presents similarly to graft versus host disease (GVHD). We report a unique case of TAMA presenting as a GVHD-like erythroderma in an elderly male with a history of benign thymoma. Cutaneous histopathological findings demonstrated vacuolar interface dermatitis with numerous dyskeratotic keratinocytes, exocytosis of lymphocytes, and a mildly acanthotic epidermis, which can be seen in several different disease processes.
View Article and Find Full Text PDFThymoma-Related Chest Pain and Dyspnea in a Middle-Aged Caucasian Female With Myasthenia Gravis and Good's Syndrome: A Case Report.
Cureus
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Department of Obstetrics and Gynecology, South Central Regional Medical Center, Laurel, USA.
Thymomas are rare tumors originating from thymic tissue, often associated with various paraneoplastic syndromes that can pose significant clinical management challenges. Myasthenia gravis, one of the most common paraneoplastic syndromes linked to thymomas, is characterized by autoantibodies targeting the neuromuscular junction, leading to muscle weakness exacerbated by repetitive use. Good's syndrome, an adult-onset immunodeficiency associated with thymomas, results in hypogammaglobulinemia and susceptibility to opportunistic infections, which can be life-threatening.
View Article and Find Full Text PDFThymoma With Myasthenia Gravis: A Study of Two Cases.
Cureus
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Thymoma is a rare, primary neoplasm of the thymus gland, commonly presenting in adults and associated with autoimmune diseases, most commonly myasthenia gravis (MG). Despite its generally indolent behavior, the variability in clinical presentation and potential for malignancy necessitates detailed evaluation and management. In this report, we present two cases: a 41-year-old male and a 39-year-old female, both of whom presented with a mediastinal mass with symptoms of myasthenia.
View Article and Find Full Text PDFThymoma-Associated Pleural Effusion Treated With Neoadjuvant Chemotherapy.
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Hematology/Oncology, Westchester Medical Center, Valhalla, USA.
Anterior mediastinal masses, including thymomas, can present with thoracic symptoms or paraneoplastic syndromes, especially in adults over 40. Diagnosis involves imaging and biopsy, and treatment includes surgical resection and chemotherapy, depending on the stage. A 31-year-old male, with a history of alcohol use disorder and a former smoker, presented with increasing heartburn, shortness of breath, left shoulder pain, and chest pain.
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