98%
921
2 minutes
20
In this paper, we consider how to incorporate psychophysical measurements of human visual perception into the loss function of a deep neural network being trained for a recognition task, under the assumption that such information can reduce errors. As a case study to assess the viability of this approach, we look at the problem of handwritten document transcription. While good progress has been made towards automatically transcribing modern handwriting, significant challenges remain in transcribing historical documents. Here we describe a general enhancement strategy, underpinned by the new loss formulation, which can be applied to the training regime of any deep learning-based document transcription system. Through experimentation, reliable performance improvement is demonstrated for the standard IAM and RIMES datasets for three different network architectures. Further, we go on to show feasibility for our approach on a new dataset of digitized Latin manuscripts, originally produced by scribes in the Cloister of St. Gall in the the 9th century.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1109/TPAMI.2021.3092688 | DOI Listing |
Physiol Plant
September 2025
Group of Antioxidants, Free Radicals and Nitric Oxide in Biotechnology, Food and Agriculture, Department of Stress, Development and Signaling in Plants, Estación Experimental del Zaidín, Spanish National Research Council (CSIC), Granada, Spain.
Waterlogging, increasingly intensified by climate change, limits oxygen availability in the root zone, disrupting carbon and sugar metabolism, leading to energy deficits and oxidative stress that ultimately impair plant growth and productivity. Melatonin, a versatile signaling molecule, mitigates waterlogging-induced stress by enhancing anaerobic respiration and fermentation under oxygen-deprived conditions, upregulating stress-responsive genes, and restoring energy balance through optimized sugar metabolism. It also reduces oxidative damage by strengthening the antioxidant defense system and further improves stress tolerance by modulating phytohormone signaling and influencing rhizosphere microbiome dynamics.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
Integrative Biology, University of Guelph, Guelph, ON, Canada.
Thyroid hormones (THs) are essential regulators of metabolism, homeostasis, and development in metazoans. The canonical genomic pathway involves THs binding to nuclear thyroid hormone receptors (NTHRs), which modulate gene expression in vertebrates. In contrast, non-genomic pathways involve THs interacting with membrane-bound or cytoplasmic receptors.
View Article and Find Full Text PDFJ Ethnopharmacol
September 2025
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing, 102400, China. Electronic address:
Ethnopharmacological Relevance: Fever is a prevalent clinical symptom and is usually caused by inflammation or infection. Persistent high fever can lead to delirium, coma and convulsions, causing brain damage. Angong Niuhuang Pill (ANP), a traditional Chinese emergency medicine, has been employed in clinical practice for centuries, with well-documented antipyretic effects.
View Article and Find Full Text PDFBMC Womens Health
September 2025
Department of Community Medicine, University of Jos, P. M. B. 2084, Jos, Plateau State, Nigeria.
Background: Nigeria is the seventh-most populous country in the world. Its high fertility rate and unmet need for family planning contribute to the increasing population size. To reduce this gap, the Federal Government of Nigeria, in collaboration with Injectables Access Collaborative and other public and private sector players, introduced the subcutaneous depot medroxyprogesterone acetate (DMPA-SC) to the contraceptive method mix in 2017.
View Article and Find Full Text PDFGigascience
January 2025
Center for Cancer Research, Comprehensive Cancer Center, Medical University of Vienna, 1090 Vienna, Austria.
Background: Pancreatic ductal adenocarcinoma (PDAC), the most common and aggressive form of pancreatic cancer, exhibits profound intratumor morphological heterogeneity, complicating the elucidation of the underlying molecular mechanisms driving its progression.
Results: We present and validate an optimized framework for RNA sequencing (RNA-seq) of multiple spatially resolved laser micro-dissected tumor areas (LMD-seq), along with methodological and analytical details to maximize reproducibility and data mining. This approach enhances sensitivity in detecting lowly expressed genes, outperforming single-cell RNA-seq methods, particularly in identifying rare tumor cell populations and transcriptional programs with low expression.