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http://dx.doi.org/10.1136/annrheumdis-2021-220642 | DOI Listing |
Rev Med Suisse
August 2025
Unité de nutrition clinique, Service de gastroentérologie et hépatologie, Hôpitaux universitaires de Genève, 1211 Genève 14.
Refeeding syndrome (RFS), which is often underdiagnosed, is a preventable condition that can be fatal if not managed early. It may occur after nutrition is reintroduced in malnourished patients or those who have experienced a prolonged reduction in food intake. As a result of the metabolic shift from a catabolic to an anabolic state, RFS is characterized by electrolyte disturbances and vitamin deficiencies, which can lead to severe clinical complications.
View Article and Find Full Text PDFCancer Res Commun
September 2025
Spanish National Cancer Research Centre, Madrid, Madrid, Spain.
Purpose: Advanced, pre-treated TNBC has a dismal prognosis and lacks effective options beyond standard cytotoxics. We previously showed, via phosphoproteomic screening, that CDK6 and ERK hyperactivation are linked to adverse outcomes and represent actionable targets. This prompted us to evaluate palbociclib and binimetinib in advanced TNBC after one or two prior therapies.
View Article and Find Full Text PDFJ Magn Reson Imaging
September 2025
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Background: Parkinson's disease (PD) often presents with lateralized motor symptoms at onset, reflecting asymmetric degeneration of the substantia nigra (SN). Neuromelanin (NM) loss and iron accumulation are hallmarks of SN pathology in PD, but their spatial distribution and interrelationship in PD patients with right-sided (PDR) or left-sided (PDL) motor symptom onset remain unclear.
Purpose: To investigate the spatial vulnerability and interrelationship of NM and iron in the SN among PDR, PDL, and healthy controls (HCs) using MRI.
Hematology
December 2025
Department of Pediatrics, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, People's Republic of China.
Background: Childhood leukaemia remains a major global health challenge and its impact varies significantly by region. Understanding the patterns of incidence, mortality, prevalence, and disability-adjusted life years (DALYs) is crucial for crafting effective public health initiatives and enhancing care outcomes, especially in regions with constrained resources.
Methods: This study evaluates the worldwide, regional, and country-specific effects of childhood leukemia between 1990 and 2021, leveraging data from the Global Burden of Disease (GBD) initiative.
J Dermatol
September 2025
Institute of Dermatology, Shanghai Children Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai, China.
No consensus was made on whether all Nevus sebaceous (NS) should undergo prophylactic excision and the best age of surgery. This is a retrospective study. Patients who underwent surgery and were confirmed as NS by pathology during January 2014 to December 2023 in the Department of Dermatology of Xinhua hospital were included in this study.
View Article and Find Full Text PDF