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The capabilities of rotational spectroscopy-based methods as tools to deliver accurate and precise chirality-sensitive information are still breaking ground, but their applicability in the challenging field of analytical chemistry is already clear. In this mini review, we explore the current abilities and challenges of two emergent techniques for chiral analysis based on rotational spectroscopy. For that, we will showcase the two methods (microwave 3-wave mixing and chiral tag rotational spectroscopy) while testing their performance to solve the absolute configuration and the enantiomeric excess of a blind sample containing a mixture of enantiomers of styrene oxide.
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http://dx.doi.org/10.1039/d0sc03752d | DOI Listing |
J Phys Chem A
September 2025
Department of Inorganic and Physical Chemistry, Indian Institute of Science Bangalore, Bengaluru560012, India.
The microwave spectrum of the complex formed between 1-fluoronaphthalene and HO has been recorded using a chirped pulse Fourier transform microwave spectrometer within the frequency range of 2.0 to 8.0 GHz, with neon as the carrier gas.
View Article and Find Full Text PDFChemMedChem
September 2025
Laboratorio de Síntesis Orgánica, Facultad de Farmacia, Universidad Central de Venezuela, Apartado 47206, Los Chaguaramos, Caracas, 1041-A, Venezuela.
Due to the advantages of drug repurposing, the discovery of new chemotherapeutic agents for the treatment of Chagas disease based on approved drugs has become a strategy for identifying new candidates. In this work, the antidepressant drug sertraline is reported, with an IC of 7.8 ± 1.
View Article and Find Full Text PDFFront Plant Sci
August 2025
Department Soil Science and Environmental Analyses, Institute of Soil Science and Plant Cultivation-State Research Institute, Puławy, Poland.
Introduction: Soil dissolved organic matter (DOM) regulates nutrient cycling and carbon sequestration, yet how cropping systems (rotation vs. monoculture) shape the vertical distribution and molecular traits of DOM remains unclear.
Methods: We leveraged a long-term experiment (est.
ACS Omega
September 2025
Optics and Photonics Group, Institute of Physics, Federal University of Mato Grosso do Sul, PO Box 549, 79070-900 Campo Grande, MS, Brazil.
The production of diesel-biodiesel blends (DBB) aims to mitigate the environmental impacts of diesel combustion. However, gaps remain in understanding their molecular properties, particularly fluorescence anisotropy (FA), which reflects molecular rotation and environmental constraints (e.g.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
September 2025
Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.
The cluster growth behavior of CO and CH on an aromatic ligand has been studied through the unambiguous identification of complex structures of 1,2,3-trifluorobenzene-(CO) and -ß(CH) using broadband rotational spectroscopy in conjunction with extensive theoretical calculations. The results reveal a contrast in the thermodynamically favorable ligand-gas binding sites and noncovalent interactions of the two gaseous molecules on the ligand. The observation of a tunneling splitting and large centrifugal distortions indicates that CH molecules bind to the fluorinated π system via three weak hydrogen bonds without CH self-interactions, resulting in an effective structure displaced toward the dissociation limit.
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