Assessing the performance of rotational spectroscopy in chiral analysis.

Chem Sci

Deutsches Elektronen-Synchrotron DESY Notkestraße 85 22607 Hamburg Germany

Published: September 2020


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Article Abstract

The capabilities of rotational spectroscopy-based methods as tools to deliver accurate and precise chirality-sensitive information are still breaking ground, but their applicability in the challenging field of analytical chemistry is already clear. In this mini review, we explore the current abilities and challenges of two emergent techniques for chiral analysis based on rotational spectroscopy. For that, we will showcase the two methods (microwave 3-wave mixing and chiral tag rotational spectroscopy) while testing their performance to solve the absolute configuration and the enantiomeric excess of a blind sample containing a mixture of enantiomers of styrene oxide.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8162261PMC
http://dx.doi.org/10.1039/d0sc03752dDOI Listing

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