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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193583 | PMC |
| http://dx.doi.org/10.1083/jcb.20200516606072021c | DOI Listing |
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Giantin mediates Golgi localization of Gal3-O-sulfotransferases and affects salivary mucin sulfation in patients with Sjögren's disease.
JCI Insight
November 2024
Departamento de Tecnología Médica, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Article Synopsis
- Sjögren's disease is a chronic autoimmune condition primarily causing dry mouth and eyes, alongside other symptoms.
- It involves reduced saliva production and changes in the quality of mucins, which are essential for mouth and eye hydration.
- A protein called Giantin is mislocalized in the salivary glands of Sjögren’s patients, disrupting its interaction with enzymes that modify mucins, potentially explaining decreased mucin sulfation in these individuals.
The Golgin Protein Giantin Regulates Interconnections Between Golgi Stacks.
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Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan.
Golgins are a family of Golgi-localized long coiled-coil proteins. The major golgin function is thought to be the tethering of vesicles, membranes, and cytoskeletal elements to the Golgi. We previously showed that knockdown of one of the longest golgins, Giantin, altered the glycosylation patterns of cell surfaces and the kinetics of cargo transport, suggesting that Giantin maintains correct glycosylation through slowing down transport within the Golgi.
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View Article and Find Full Text PDFA role for the Golgi matrix protein giantin in ciliogenesis through control of the localization of dynein-2.
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The correct formation of primary cilia is central to the development and function of nearly all cells and tissues. Cilia grow from the mother centriole by extension of a microtubule core, the axoneme, which is then surrounded with a specialized ciliary membrane that is continuous with the plasma membrane. Intraflagellar transport moves particles along the length of the axoneme to direct assembly of the cilium and is also required for proper cilia function.
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