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The Greenland ice sheet has been one of the largest sources of sea-level rise since the early 2000s. However, basal melt has not been included explicitly in assessments of ice-sheet mass loss so far. Here, we present the first estimate of the total and regional basal melt produced by the ice sheet and the recent change in basal melt through time. We find that the ice sheet's present basal melt production is 21.4 +4.4/-4.0 Gt per year, and that melt generated by basal friction is responsible for about half of this volume. We estimate that basal melting has increased by 2.9 ± 5.2 Gt during the first decade of the 2000s. As the Arctic warms, we anticipate that basal melt will continue to increase due to faster ice flow and more surface melting thus compounding current mass loss trends, enhancing solid ice discharge, and modifying fjord circulation.
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http://dx.doi.org/10.1038/s41467-021-23739-z | DOI Listing |
Toxins (Basel)
August 2025
Department of Clinical Neurological Sciences, Western University, London, ON N6A 3K7, Canada.
The primary effect of Botulinum toxin (BoNT) is to cause weakness in the injected muscles by inhibiting the release of acetyl choline from presynaptic nerve terminals. Its effect on sensorimotor integration (SMI) has largely been confined to small studies. The aim of this review is to highlight effect of BoNT on SMI in the context of Parkinson's disease (PD), Cervical dystonia (CD), and Writer's cramp (WC).
View Article and Find Full Text PDFBrain Imaging Behav
August 2025
First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
This study aims to investigate glymphatic system dysfunction in idiopathic Parkinson's disease (PD) using a dual-cohort design, focusing on its associations with freezing of gait (FOG) and cognitive decline. A cross-sectional analysis was conducted on 43 PD patients with FOG, 106 without FOG, and 46 healthy controls. A longitudinal study followed 146 early-stage PD patients from the Parkinson's Progression Markers Initiative database over five years, with 65 developing FOG.
View Article and Find Full Text PDFFront Neurosci
July 2025
Department of Neurology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
Introduction: Parkinson's disease (PD)-associated freezing of gait (FoG) (PDFoG) refers to episodes where patients feel the urge to move but experience temporary immobility or markedly shortened steps. This leads to frequent falls and, eventually, the loss of walking ability, severely affecting patient quality of life and life expectancy. Despite its clinical importance, the neural mechanisms underlying PDFoG remain unclear.
View Article and Find Full Text PDFBrain Commun
July 2025
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94304, USA.
Freezing of gait is a debilitating symptom of Parkinson's disease that is often refractory to medication. Prolonged beta bursts within the subthalamic nucleus are associated with worse impairment and freezing, which are improved with deep brain stimulation. The goal of the study was to investigate the feasibility, safety and tolerability of beta burst-driven adaptive deep brain stimulation for gait impairment and freezing of gait in Parkinson's disease.
View Article and Find Full Text PDFNeuroSci
June 2025
Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University, 40225 Düsseldorf, Germany.
Transcranial pulse stimulation (TPS) is a non-invasive neuromodulation method that uses, high-intensity acoustic shockwaves to deliver focused mechanical stimulation to neural tissue with minimal thermal effects. The mechanism of action includes but is not limited to promotion of blood flow and angiogenesis through mechanotransduction. Clinical data to date are limited and preliminary.
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