Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8284432 | PMC |
| http://dx.doi.org/10.1128/AAC.00695-21 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The vast majority of persons living with HIV-1 who discontinue antiretroviral therapy (ART) demonstrate viral rebound, but the tissue-level events that lead to rebound viremia are poorly understood. Here we report the origin, dynamics, and correlates of viral rebound in 16 rhesus macaques (RMs) infected with molecularly barcoded SIVmac239M, treated with ART for 70 weeks, and necropsied on day 12 after ART discontinuation. Barcode analysis of plasma following ART discontinuation identified 1 to 38 rebounding barcode-defined viral lineages per animal, with 1 to 4 rebounding lineages contributing to first measurable rebound viremia.
View Article and Find Full Text PDFEvaluation of the Roche cobas MTB and MTB-RIF/INH for detecting Mycobacterium tuberculosis complex and resistance to isoniazid and rifampicin: A prospective, multicenter diagnostic accuracy study.
Int J Antimicrob Agents
September 2025
Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Laboratory Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan; Department of Laboratory Medicine, National Taiwan U
Objectives: To evaluate the diagnostic performance of Roche cobas MTB and MTB-RIF/INH assays for detecting Mycobacterium tuberculosis complex (MTBC) and resistance to isoniazid (INH) and rifampicin (RIF).
Methods: This multicenter study was conducted in Taiwan between September 2023 and June 2024. Clinical specimens were collected from adult patients with presumptive tuberculosis (TB).
Performance of Tongue Swabs for Tuberculosis Diagnosis in Hospitalized Children Under 5 Years of Age.
Open Forum Infect Dis
September 2025
DSI/NRF Centre of Excellence for Biomedical TB Research, Faculty of Health Sciences, University of the Witwatersrand, National Health Laboratory Service, Johannesburg, South Africa.
Background: Tuberculosis (TB) diagnosis remains difficult in children under 5 years of age (under-5s), who have high TB morbidity and mortality rates. In a high-burden TB setting, we investigated the diagnostic characteristics of Xpert MTB/RIF Ultra testing of tongue swabs (TS-XU) collected from under-5s.
Methods: In a masked, prospective, observational study, tongue swabs were collected from enrolled hospitalized under-5s deemed high risk for TB disease who were categorized into 1 of the following: confirmed, unconfirmed, or unlikely TB.
Computational Evaluation of the Use of Fluorescein Isothiocyanate as a Preliminary Test for Amphetamines and Cathinones.
ACS Omega
August 2025
Departmento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo. Avenida Bandeirantes, 3900 - CEP, 14040-901 Ribeirão Preto, SP, Brazil.
The rise of new psychoactive substances (NPS) challenges traditional drug detection, especially in initial analyses. This research investigates fluorescein isothiocyanate (FITC) as a potential colorimetric reagent for detecting amphetamines and related cathinones through computational and mechanistic methods. Forty-two amphetamine-type stimulants were examined using density functional theory (DFT) and UV-vis spectra via TD-DFT.
View Article and Find Full Text PDFDevelopment and validation of a risk prediction model for pulmonary tuberculosis in presumptive tuberculosis patients in Tigray, northern Ethiopia.
Sci Rep
September 2025
School of Public Health, College of Health Sciences, Mekelle University, Mekelle, Ethiopia.
The incidence of tuberculosis (TB) has increased in Tigray, Ethiopia due to war and a crippled healthcare system. Although early detection and treatment are critical for TB control, over 30% of TB cases are missed using current diagnostic techniques. Thus, we developed and validated a risk prediction model for pulmonary TB in presumptive cases.
View Article and Find Full Text PDF