Dual-energy CT of the liver: True noncontrast vs. virtual noncontrast images derived from multiple phases for the diagnosis of fatty liver.

Purpose: To evaluate the difference in liver density and to compare the performance to diagnose fatty liver between true noncontrast (TNC) images and virtual noncontrast (VNC) images generated from dual-energy CT (DECT).

Materials And Methods: Patients who underwent liver dynamic DECT and MRI were included (n = 49). Two observers measured the liver and spleen densities on TNC images and three VNC images from the arterial, portal and delayed phases of DECT (VNCa, VNCp and VNCd, respectively). The liver-minus-spleen density (density L-S) and liver-to-spleen ratio (density L/S) were calculated. The CT parameters were compared between normal liver patients and fatty liver patients by using the independent t-test. Differences and agreements between measurements on TNC images and VNC images were evaluated by using the paired t-test and Bland-Altman analysis. Receiver operating characteristic (ROC) curve analysis was used to evaluate the diagnostic performance of CT parameters for diagnosing fatty liver.

Results: All CT parameters measured on TNC and VNC images were significantly higher in normal liver patients than in fatty liver patients. Although the mean liver densities on VNC images were significantly lower than those on TNC images, all CT parameters showed good agreement between TNC images and VNC images. The diagnostic performances of CT parameters on VNC images were not significantly different from those on TNC images.

Conclusion: Although the liver and spleen density on VNC images was significantly lower than that on TNC images, the diagnostic performances of CT parameters on three VNC images from multiple phases were similar to those on TNC images for diagnosing fatty liver.