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http://dx.doi.org/10.1038/s41436-021-01099-9 | DOI Listing |
J Refract Surg
September 2025
JENVIS Research, Jena, Germany.
Purpose: To analyze the difference in objective and subjective photic phenomena following virtual implantation of three different presbyopia-correcting diffractive intraocular lens (IOL) designs.
Methods: The study was conducted at JENVIS Research Germany. A prospective cross-over and double-masked trial design was used.
Knee Surg Sports Traumatol Arthrosc
September 2025
Department of Orthopaedics and Trauma Surgery, Medical University of Innsbruck, Innsbruck, Austria.
Purpose: Modifying interference screw composition may ensure better osteoconductive properties in order to reduce tunnel enlargement after anterior cruciate ligament (ACL) reconstruction. The primary and secondary purposes were to evaluate tunnel and screw volume changes in poly-L-lactide acid (PLLA) and poly-D-lactic acid + hydroxyapatite + β-tricalcium phosphate (PLDLA+) screws. The tertiary purpose was to compare patient reported- and functional outcomes between PLLA and PLDLA+ group.
View Article and Find Full Text PDFJ Biopharm Stat
September 2025
Biostatistics and Research Decision Sciences, Merck & Co. Inc., North Wales, Pennsylvania, USA.
A randomized clinical trial with multiple experimental groups and one common control group is often used to speed up development to select the best experimental regimen or to increase the chance of success of clinical trials. Most of the time, multiple dose levels of an experimental drug or multiple combinations of one experimental drug with other drugs comprise multiple experimental groups. Because the experimental drug appears in multiple comparisons with a shared control group, multiple testing adjustments to control the family-wise type I error rate are needed.
View Article and Find Full Text PDFOrthod Craniofac Res
September 2025
Georgia School of Orthodontics, Atlanta, Georgia, USA.
Management of class III malocclusion in patients with cleft is geared toward improving the maxillary position with maxillary protraction therapy with or without bone anchorage. This study aims at evaluating the effects of bone-anchored maxillary protraction (BAMP) and tooth-anchored maxillary protraction (TAMP) appliances in patients with cleft lip and palate (CLP). A search of PubMed MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Web of Science, ProQuest Dissertations and Theses Global, and ClinicalTrials.
View Article and Find Full Text PDFJB JS Open Access
September 2025
OLVG, Orthopedic Surgery Department, Amsterdam, the Netherlands.
Background: Evidence supporting surgery in elderly patients with distal radius fractures is limited, but displaced fractures may benefit from surgery. This study aimed to determine whether casting is noninferior to surgery for patients aged 65 years or older with substantially displaced intra-articular (AO type C) distal radius fractures.
Methods: This multicenter randomized controlled noninferiority trial included 138 patients (mean age 76 years, SD 6.