Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Quantitative variation in expression of the floral repressor influences whether plants overwinter before flowering, or have a rapid cycling habit enabling multiple generations a year. Genetic analysis has identified activators and repressors of expression but how they interact to set expression level is poorly understood. Here, we show that antagonistic functions of the activator FRIGIDA (FRI) and the repressor FCA, at a specific stage of embryo development, determine expression and flowering. FRI antagonizes an FCA-induced proximal polyadenylation to increase expression and delay flowering. Sector analysis shows that FRI activity during the early heart stage of embryo development maximally delays flowering. Opposing functions of cotranscriptional regulators during an early embryonic developmental window thus set expression levels and determine flowering time.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8092400 | PMC |
| http://dx.doi.org/10.1073/pnas.2102753118 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Rational nutrition as a factor of healthy lifestyle and prevention of chronic non-communicable diseases.
Pol Merkur Lekarski
September 2025
VOLODYMYR DAHL EAST UKRAINIAN NATIONAL UNIVERSITY, KYIV, UKRAINE.
Objective: Aim: The aim is to conduct medical and sociological research on public awareness of the impact of rational nutrition on promoting human health and preventing chronic non-communicable diseases.
Patients And Methods: Materials and Methods: The research was conducted in 2022-2024 and involved 214 respondents of different ages and genders who were patients of outpatient clinics in Zhytomyr (Ukraine). Research methods included theoretical analysis of literary sources, medical and sociological (questionnaire), mathematical and statistical, system analysis, and logical generalization.
Global transcriptional analysis of human FHs 74 Int intestinal epithelial cells after exposure to advanced glycation end products.
PLoS One
September 2025
Institute of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology & Immunology, Medical University of Vienna, Vienna, Austria.
Advanced glycation end products (AGEs) and reactive intermediates, such as methylglyoxal, are formed during thermal processing of foods and have been implicated in the pathogenesis of a series of chronic inflammatory diseases. AGEs are thought to directly interact with the intestinal epithelium upon ingestion of thermally processed foods, but their effects on intestinal epithelial cells are poorly understood. This study investigated transcriptomic changes in human intestinal epithelial FHs 74 Int cells after exposure to AGE-modified human serum proteins (AGE-HS), S100A12, a known RAGE ligand, and unmodified human serum proteins (HS).
View Article and Find Full Text PDFThe effect of face masks on confusion of emotional expressions.
PLoS One
September 2025
Department of Psychology & Sociology, Texas A&M University - Corpus Christi, Corpus Christi, Texas, United States of America.
While the use of personal protective equipment protects healthcare workers against transmissible disease, it also obscures the lower facial regions that are vital for transmitting emotion signals. Previous studies have found that face coverings can impair recognition of emotional expressions, particularly those that rely on signals from the lower regions of the face, such as disgust. Recent research on the individual differences that may influence expression recognition, such as emotional intelligence, has shown mixed results.
View Article and Find Full Text PDFIdentification and prioritization of gene sets associated with schizophrenia risk by network analysis.
Psychopharmacology (Berl)
September 2025
Institute of Cardiovascular Research, Sleep Medical Center, Department of Psychiatry, Fundamental and Clinical Research on Mental Disorders Key Laboratory of Luzhou, Affiliated Hospital, Southwest Medical University, Luzhou, Sichuan Province, 646000, China.
Rationale: Genome-wide association studies (GWASs) are used to identify genetic variants for association with schizophrenia (SCZ) risk; however, each GWAS can only reveal a small fraction of this association.
Objectives: This study systematically analyzed multiple GWAS data sets to identify gene subnetwork and pathways associated with SCZ.
Methods: We identified gene subnetwork using dmGWAS program by combining SCZ GWASs and a human interaction network, performed gene-set analysis to test the association of gene subnetwork with clinical symptom scores and disease state, meanwhile, conducted spatiotemporal and tissue-specific expression patterns and cell-type-specific analysis of genes in the subnetwork.
Aucubin inhibits the activity of lung cancer stem-like cells by targeting degradation of β-catenin.
J Pharm Pharmacol
September 2025
Department of Clinical Pharmacy, Hebei Medical University Third Hospital. No. 139 Ziqiang Road, Qiaoxi District, Shijiazhuang 050051, China.
Objectives: To investigate the antitumor effects of aucubin (AC) in non-small cell lung cancer (NSCLC) and uncover its plausible mechanism against lung cancer stem-like cells (LCSCs).
Methods: In vitro experiments included MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, a reagent commonly used for cell viability assay) and colony formation assays to assess anti-proliferative effects on A549 and NCI-H1975 lung cancer cell lines, wound healing and Transwell invasion assays to evaluate inhibition of cell migration and invasion, tumorsphere-formation experiments to detect changes in NSCLC cell stemness, as well as Western blot and quantitative reverse transcription polymerase chain reaction (qRT-PCR) analyses to measure the expression of LCSC markers (CD44, CD133, Oct4, and Nanog). In vivo experiments were conducted to observe the impact of AC on NSCLC metastasis and mouse survival rates.