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The bacterial mechanosensitive channel of small conductance (MscS) is a well-studied model of how mechanical forces from the membrane can be sensed by an embedded protein. A recent study by Zhang et al. visualizes how MscS behaves under membrane tension, entering a desensitized state when it loses all coordinated lipids.
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http://dx.doi.org/10.1016/j.tibs.2021.04.002 | DOI Listing |
Int J Surg Case Rep
September 2025
Institute of Orthopedics and Traumatology, Military Hospital 175, Ho Chi Minh City, 70000, Viet Nam. Electronic address:
Introduction: Proximal humeral fracture-dislocations (PHF-D) are complex injuries, often requiring urgent intervention. However, management protocols remain unclear when anatomical reduction of the glenohumeral joint is achieved, but significant displacement of the greater tuberosity persists. The lack of consensus on whether to reclassify such injuries after reduction creates uncertainty in rehabilitation strategies.
View Article and Find Full Text PDFJ Occup Rehabil
September 2025
Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal (CRIR), Montréal, QC, Canada.
Purpose: Physiotherapists play a central role in the rehabilitation of individuals with work-related musculoskeletal disorders. Yet, it is currently unclear how entry-level training prepares them to manage work disability. This study aimed to (1) identify a set of work rehabilitation competencies, (2) examine how these competencies are integrated into entry-level physiotherapy training programs in Quebec, Canada, and (3) assess educators' perceptions of the adequacy of work rehabilitation education.
View Article and Find Full Text PDFJ Clin Pharmacol
September 2025
CSL Behring LLC, King of Prussia, PA, USA.
Garadacimab is a novel, fully human, anti-activated factor XII monoclonal antibody approved for long-term prophylaxis of patients with hereditary angioedema. This open-label, parallel-group, Phase 1, single-center, bridging study in healthy adults (18-55 years of age) characterized the pharmacokinetics and safety of a single 200 mg subcutaneous injection of garadacimab administered via autoinjector/pre-filled pen (AI/PFP) compared with the pre-filled syringe (PFS) used in previous studies. The aim of the study was to bridge the understanding of the PK and safety of garadacimab between PFS and AI/PFP modes of administration.
View Article and Find Full Text PDFJ Robot Surg
September 2025
Department of Urology, Medical Faculty Carl Gustav Carus, TU Dresden, Fetscherstr. 74, 01307, Dresden, Germany.
Robot-assisted surgery is increasingly preferred. New systems such as the Hugo™RAS enter the market, offering different pricing and modular architecture. While daVinci systems dominate U.
View Article and Find Full Text PDFBull Cancer
September 2025
Direction des soins, centre hospitalier de Brive, 2, boulevard du Dr-Verlhac, 19100 Brive, France. Electronic address:
Multiple myeloma is a haematologic malignancy of the bone marrow with an increasing incidence, primarily affecting an elderly and frail population. It benefits from innovative treatments that have been shown to extend patient survival. However, 2% of patients die from infections during the first year of treatment, despite the availability of prophylactic treatments.
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