More Than Just Closed and Open: Unraveling a Mechanosensor.

Trends Biochem Sci

Biocenter and Rudolf-Virchow-Zentrum, Universität Würzburg, Haus D15, Josef-Schneider-Str. 2, 97080 Würzburg, Germany. Electronic address:

Published: August 2021


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Article Abstract

The bacterial mechanosensitive channel of small conductance (MscS) is a well-studied model of how mechanical forces from the membrane can be sensed by an embedded protein. A recent study by Zhang et al. visualizes how MscS behaves under membrane tension, entering a desensitized state when it loses all coordinated lipids.

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http://dx.doi.org/10.1016/j.tibs.2021.04.002DOI Listing

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