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Two cases of neural tube defects with dolutegravir use at conception in south Brazil. | LitMetric

Two cases of neural tube defects with dolutegravir use at conception in south Brazil.

Braz J Infect Dis

Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil; Federal University of Rio Grande do Sul, School of Medicine, Porto Alegre, RS, Brazil. Electronic address:

Published: May 2021


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Article Abstract

Dolutegravir (DTG) is amongst the most prescribed antiretrovirals worldwide and is recommended as first line regimen in most HIV treatment guidelines. Its use, although infrequently, had been associated to an increased chance of neural tube defects (NTD) in Botswana, Africa. Herein we describe two cases of NTD in women who conceived while taking DTG as part of their antiretroviral treatment in the city of Porto Alegre, Brazil.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9392187PMC
http://dx.doi.org/10.1016/j.bjid.2021.101572DOI Listing

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