98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8251309 | PMC |
http://dx.doi.org/10.1111/all.14827 | DOI Listing |
Health Sci Rep
September 2025
Department of Science and Mathematics, School of Interdisciplinary Arts and Sciences University of Washington Tacoma Tacoma Washington USA.
Background And Aims: Understanding the determinants of humoral immunity following COVID-19 infection is essential for guiding vaccination and public health strategies. This study aimed to investigate the association between cycle threshold (Ct) values and SARS-CoV-2-specific antibody reactivity 1 month after recovery in a Middle Eastern cohort, and to identify other contributing factors.
Methods: A case-control study was conducted among COVID-19 patients registered in the Qatar Biobank between March and September 2020.
Vaccines (Basel)
July 2025
Department of Medicine, Gødstrup Hospital, 7400 Herning, Denmark.
Background: Kidney transplant recipients (KTRs) exhibit a significantly diminished immune response to Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) vaccines compared with the general population, primarily due to ongoing immunosuppressive therapy. This study evaluated the immunogenicity of a third SARS-CoV-2 mRNA vaccine dose in KTRs and assessed the association between antibody response and protection against SARS-CoV-2 breakthrough infection. Additionally, the clinical and immunological correlates of post-vaccination SARS-CoV-2 infection were examined.
View Article and Find Full Text PDFToxicol Lett
August 2025
Department of Radiology and Radiodiagnostics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Jordana 19, Zabrze 41-808, Poland. Electronic address:
Background: The adaptive immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is characterized by the production of various antibodies, with immunoglobulin M (IgM) being the initial isotype synthesized. Lead (Pb), a toxic heavy metal, accumulates in biological systems and disrupts multiple biochemical processes, potentially modulating immune function through alterations in cytokine production and antibody levels.
Objective: This study aimed to elucidate the early immune response to SARS-CoV-2 in lead-exposed individuals by examining antibody profiles and associated immunological parameters.
Curr Res Microb Sci
July 2025
Departamento de Enfermedades Infecciosas e Inmunología Pediátricas, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
During the SARS-CoV-2 pandemic, the use of convalescent plasma (CP) in high-risk patients was proposed and widely implemented in several countries as a potential COVID-19 therapy. Nonetheless, CP therapy's impact on immune response is nowadays poorly understood, including the correlation between IgG levels, neutralization capacity, and cellular immune response against SARS-CoV-2. Here we evaluated, in a cohort of patients with COVID-19 requiring hospitalization and having received or not CP, as well as in CP donors (recovered from mild disease), the humoral and cellular immune response assessed by titers of SARS-CoV-2 IgG, neutralizing antibodies, and IFN-γ/IL-2 ELISpot during the first month (early) and up to nine months (long-term) after symptom onset.
View Article and Find Full Text PDFPeerJ
July 2025
Cell Culture and Immunology Lab, Universidad Cientifica del Sur, Lima, Peru.
Background: Evaluating both humoral and cellular immunity is essential for optimizing vaccination strategies and preventing post-pandemic SARS-CoV-2 outbreaks. This cross-sectional study assessed cellular immunity by measuring mRNA expression and humoral immunity through SARS-CoV-2-specific IgG antibodies.
Method: Whole blood samples were collected from 40 Peruvian volunteers.