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http://dx.doi.org/10.1111/liv.14861 | DOI Listing |
Mol Biol Rep
August 2025
Chemistry Department (Biochemistry Division), Faculty of Science, Port Said University, Port Said, 42526, Egypt.
Background And Objective: Patients with liver cirrhosis (LC) are at the highest risk of developing hepatocellular carcinoma (HCC). Thus, this research aimed to clarify the tumorigenic potential of PTX3 and ALDH implicated in HCC development and to find a novel diagnostic model for predicting HCC earlier in liver cirrhotic Egyptian patients.
Patients And Methods: 88 patients hospitalized at Gastrointestinal Surgery Center for liver transplantation; 63 HCV-chronic liver disease patients after successful Direct acting antiviral (DAA) therapy (30 HCC patients on top of LC and 33 LC patients) and 25 Non-viral LC in addition to 25 healthy individuals.
Cureus
July 2025
Internal Medicine, Northside Hospital Cherokee, Canton, USA.
We report a rare case of a 65-year-old man with decompensated cirrhosis due to alcohol and HCV, who presented with altered mental status, hypotension, and a diffuse rash. Laboratory findings were notable for leukocytosis, severe coagulopathy, and acute kidney injury. Peripheral smear and flow cytometry confirmed intravascular large B-cell lymphoma (IVLBCL), a rare and aggressive subtype of non-Hodgkin lymphoma characterized by intravascular proliferation of malignant lymphocytes.
View Article and Find Full Text PDFAsian Pac J Cancer Prev
July 2025
Department of Biochemistry, Biotechnology Research Institute, High Throughput Molecular and Genetic laboratory, Center for Excellences for Advanced Sciences, National Research Centre, Dokki, Giza, Egypt.
Background: Hepatocellular carcinoma (HCC) is the most prevalent form of primary liver cancer in Egypt, largely due to the widespread presence of hepatitis C virus. Symptoms of HCC often appear only at an advanced stage, making early detection essential through advanced methods. This study aimed to explore the association between the rs4444903 gene polymorphism in the epidermal growth factor and the likelihood of developing HCC in individuals with cirrhosis.
View Article and Find Full Text PDFHum Pathol
September 2025
Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. Electronic address:
Background: Extensive ductular proliferation can mimic well-differentiated cholangiocarcinoma, but such pseudo-tumorous lesion has not been well described in the literature. Our study sought to evaluate the clinicopathologic features of such cases.
Design: Four cases with reactive ductular proliferation that mimicked cholangiocarcinoma microscopically and also appeared grossly to form a mass/nodule were identified from 1995 to 2024 at two large academic health institutions.
Niger Med J
June 2025
Department of Medicine, Federal teaching Hospital, Gombe, Nigeria.
Advanced chronic liver disease is frequently complicated by hepatic encephalopathy (HE), hepatorenal syndrome, and spontaneous bacterial peritonitis; predictors of poor prognosis that significantly reduce survival. While orthotopic liver transplantation (OLT) remains the definitive treatment, it is often inaccessible in resource-limited settings. We present the case of a 70-year-old retired hospital attendant with hypertension who developed decompensated liver cirrhosis secondary to chronic hepatitis C virus HCV infection.
View Article and Find Full Text PDF