Where have all the Orais gone? Commentary on "Orai1 channels are essential for amplification of glutamate-evoked Ca signals in dendritic spines to regulate working and associative memory".

Cell Calcium

Institute of Neuroscience, Technical University Munich, Biedersteiner Str. 29, 80802, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Biedersteiner Str. 29, 80802, Munich, Germany.

Published: June 2021


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Article Abstract

Orai1 channels were reported as critical contributors to the Ca signal in hippocampal neurons underlying synaptic plasticity associated with learning and memory. We discuss the results in view of conflicting other reports that stressed the roles of Orai2 channels but failed to detect functions of Orai1 channels in these neurons.

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http://dx.doi.org/10.1016/j.ceca.2021.102372DOI Listing

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