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Orai1 channels were reported as critical contributors to the Ca signal in hippocampal neurons underlying synaptic plasticity associated with learning and memory. We discuss the results in view of conflicting other reports that stressed the roles of Orai2 channels but failed to detect functions of Orai1 channels in these neurons.
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http://dx.doi.org/10.1016/j.ceca.2021.102372 | DOI Listing |
J Cyst Fibros
August 2025
Division of Genetic, Environmental and Inhalational Disease, Department of Internal Medicine, Kansas University Medical Center, Kansas City, KS, 66103, USA. Electronic address:
Rationale: People with cystic fibrosis (pwCF) exhibit chronic and hyperactive neutrophilia which results in a progressive loss of lung function. CF neutrophils have elevated store operated Ca entry (SOCE) relative to healthy non-CF neutrophils, which contributes to persistent neutrophilia. The vast majority of pwCF now take CFTR modulators such as elexacaftor/tezacaftor/ivacaftor (ETI), which effectively increase CFTR function in multiple organs including the lung.
View Article and Find Full Text PDFBiomed Pharmacother
August 2025
Channelopathy Research Center (CRC), Dongguk University College of Medicine, 32 Dongguk-ro, Ilsan Dong-gu, Goyang, Gyeonggi-do 10326, South Korea; Department of Internal Medicine, Graduate School of Medicine, Dongguk University, 27 Dongguk-ro, Ilsan Dong-gu, Goyang, Gyeonggi-do 10326, South Korea. E
Background: Allergic rhinitis (AR) affects approximately 400 million people globally and causes rhinorrhea, nasal congestion, and sneezing. Nonetheless, current treatments often provide incomplete relief and have side effects. Recent studies have indicated that various ion channels contribute to AR symptoms, suggesting that multichannel targeting may offer a more effective treatment.
View Article and Find Full Text PDFBiochim Biophys Acta Rev Cancer
August 2025
Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China. Electronic address:
Calcium ions (Ca), pivotal regulators of tumour progression, drive cancer metastasis and therapy resistance via STIM1-mediated store-operated calcium entry (SOCE). This review focuses on the role of STIM1 and SOCE-mediated calcium signalling in various cancer types, with particular emphasis on oral cancer as a key area of our research, and future research directions in these areas are proposed. Specifically, this review reveals the mechanism by which the STIM1/Orai1 complex activates calmodulin (CaM)-dependent effectors to promote epithelial-mesenchymal transition (EMT) and remodelling of the cytoskeleton and immunosuppressive microenvironment.
View Article and Find Full Text PDFWe tested the hypothesize that the ubiquitous store-operated Ca2+ entry (SOCE) contributes to histone-induced endothelial cell Ca2+ events. We also considered an alternate hypothesis: cationic electrostatic interactions between histones and negatively charged phospholipids, deforming endothelial cell membranes and thereby allowing extracellular Ca2+ entry. A role for SOCE in histone responses was ruled out by genetic ablation of the ORAI1/2/3 channel trio; histone effects were blocked by application of the multivalent cation gadolinium Gd3+.
View Article and Find Full Text PDFFEBS J
August 2025
Department of Physiology and Pharmacology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Canada.
Calcium (Ca) is critical for normal cell function, and several protein networks are required for Ca signaling. In the pancreas, regulated changes in cytosolic Ca allow for the exocytosis of zymogen granules, and altered Ca signaling underlies pancreatic pathologies. Previously, our laboratory showed a pancreas-specific isoform of secretory pathway Ca-ATPase 2 (also known as calcium-transporting ATPase type 2C member 2; SPCA2), termed SPCA2C (gene name Atp2c2c, C-terminally truncated form), affects multiple pathways involved in Ca homeostasis.
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