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Gastric varices (GV) carry a high risk of massive hemorrhage because of potential rupture. To reduce the risk associated with GV, patients need to undergo hemostatic and preventive treatment. The objective of this retrospective study was to evaluate the usefulness of a new method, direct forward-viewing endoscopic ultrasonography (DFV-EUS) for the treatment of GV. We performed endoscopic injection sclerotherapy with histoacryl (EIS-HA) using DFV-EUS for GV in four patients. The paracentesis success rate was 75% (3/4). DFV-EUS has a significant advantage for the treatment of GV in that it can show physicians endoscopic and ultrasound views in real time during the delivery of the sclerosant into the GV. However, the proper use of the ultrasound view must be elucidated through further research for safer and more effective therapy. In the presence of distance between the mucosal surface and vascular lumen or when the blood flow site requires puncture as an additional treatment, DFV-EUS might be a good candidate for the treatment of GV. Altogether, EIS-HA with DFV-EUS might be a new therapeutic option for patients with GV.
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http://dx.doi.org/10.1159/000510132 | DOI Listing |
Gastrointest Endosc
September 2025
Department of Gastroenterology, The First Affiliated Hospital of Zhejiang University, Hangzhou 310003, China. Electronic address:
BMC Gastroenterol
September 2025
Faculty of Medicine, AL-Neelain University, Khartoum, Sudan.
Background: Upper gastrointestinal bleeding remains a significant medical emergency with considerable morbidity and mortality rates. Esophagogastroduodenoscopy is a key procedure because of its diagnostic and therapeutic value. Understanding the clinical picture as well as the expected endoscopic variations in the area can potentially improve fatal complications.
View Article and Find Full Text PDFDig Dis Sci
September 2025
Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, 110070, India.
Background: Bleeding from esophageo-gastric varices is a serious complication related to portal hypertension. In patients with cirrhosis, liver and splenic stiffness measurements (LSM and SSM) are useful to predict high-risk varices, bleeding and decompensation. Data regarding the utility of SSM for predicting bleeding in patients with non-cirrhotic portal hypertension (NCPH) is scarce.
View Article and Find Full Text PDFLiver Int
October 2025
Division of Gastroenterology and Hepatology, University of Texas at Austin, Dell Medical School, Austin, Texas, USA.
Background And Aims: Portal hypertension is the principal driver of cirrhosis decompensation, leading to heightened morbidity and mortality. While non-selective beta-blockers (NSBBs) remain the standard of care, up to 45% of patients fail to achieve sufficient portal pressure reduction. Statins have gained attention as a potential therapeutic agent for portal hypertension.
View Article and Find Full Text PDFWorld J Crit Care Med
September 2025
Department of Medicine and Pharmacology, Texas A and M University, College Station, TX 77843, United States.
The Sengstaken-Blakemore tube (SB tube), introduced in the 1950s, was a pivotal device for managing acute gastrointestinal (GI) bleeding, particularly from esophageal varices. This multi-lumen tube, featuring esophageal and gastric balloons, applied mechanical pressure to control bleeding and provided a temporary solution until more definitive treatments could be employed. It was historically significant in resource-limited settings where advanced endoscopic options were unavailable, enabling patient stabilization and transfer to specialized centers.
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