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http://dx.doi.org/10.19102/icrm.2021.120107S | DOI Listing |
Ann Nucl Med
September 2025
Department of Molecular Imaging and Theranostics, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology (QST), 4-9-1 Anagawa, Inage-ku, Chiba City, Chiba, 263-8555, Japan.
Purpose: This first-in-human study aimed to assess the biodistribution, radiation dosimetry, and safety of the novel PET tracer [3-C]AIB, a putative System A amino acid transport probe, in healthy volunteers.
Methods: Six healthy male participants underwent whole-body PET/CT scans following a rapid intravenous bolus of [3-C]AIB (injected dose: 366.9 ± 17.
J Neurointerv Surg
July 2024
JJ Merland Department of Therapeutic Neuroangiography of Hospital Universitari General de Catalunya, Hospital del Mar, Barcelona, Spain.
Background: Endovascular embolization is frequently used for vascular lesions of the head and neck. Newer agents may help to enhance visualization and improve treatment outcomes.
Methods: The CLARIDAD clinical trial was a prospective, single center, first-in-man investigation of neurovascular embolization using the novel embolic agent Obtura for a broad indication, covering the need for a liquid embolic agent in head and neck procedures.
Eye (Lond)
November 2024
Sussex Eye Hospital, University Hospitals Sussex NHS Foundation Trust, Eastern Road, BN2 5BF, Brighton, UK.
Background/objectives: Giant cell arteritis (GCA) is an inflammatory vascular disease in which prompt and accurate diagnosis is critical. The efficacy of temporal artery biopsy (TAB) is limited by 'skip' lesions and a delay in histological analysis. This first-in-man ex-vivo study aims to assess the accuracy of optical frequency domain imaging (OFDI) in diagnosing GCA.
View Article and Find Full Text PDFFront Cardiovasc Med
September 2023
Mayo Clinic Rochester, Rochester, MN, United States.
The aortic valve is the most frequently diseased valve and aortic stenosis (AS) is the most prevalent valvular heart disease in developed countries. The diseased native aortic valve can be replaced by either a biological or mechanical valve prosthesis. The main concerns relate to durability, the need for oral anticoagulants and the incidence of complications related to this medication.
View Article and Find Full Text PDFJ Transl Med
February 2023
Neurodegenerative Diseases Department, Kadimastem Ltd, Pinchas Sapir 7, Weizmann Science Park, Ness-Ziona, Israel.
Background: Malfunction of astrocytes is implicated as one of the pathological factors of ALS. Thus, intrathecal injection of healthy astrocytes in ALS can potentially compensate for the diseased astrocytes. AstroRx® is an allogeneic cell-based product, composed of healthy and functional human astrocytes derived from embryonic stem cells.
View Article and Find Full Text PDF